Turner D A, Shribman A J, Smith G, Achola K J
Br J Anaesth. 1986 Dec;58(12):1365-70. doi: 10.1093/bja/58.12.1365.
The catecholamine and cardiovascular responses to intubation were investigated during halothane anaesthesia. Thirty patients were allocated randomly to two groups. Following induction of anaesthesia and muscle relaxation, group 1 was ventilated with 70% nitrous oxide in oxygen before intubation; group 2 received 1% halothane in addition. After intubation, both groups received 0.5% halothane. Arterial pressure and heart rate, and plasma noradrenaline and adrenaline concentrations were measured throughout the induction sequence. In group 1 intubation was associated with increases (from pre-induction values) in systolic arterial pressure of 13% and diastolic arterial pressure of 35%, although the plasma concentrations of noradrenaline did not alter significantly. In group 2, although there was a pressor response to intubation, no overall change in systolic arterial pressure and only a 13% increase in diastolic arterial pressure occurred when compared with pre-induction values. This response was associated with a 78% increase in the noradrenaline concentration; the adrenaline concentration did not alter significantly.
在氟烷麻醉期间，研究了对气管插管的儿茶酚胺和心血管反应。30例患者随机分为两组。麻醉诱导和肌肉松弛后，第1组在插管前用70%氧化亚氮加氧气通气；第2组另外加用1%氟烷。插管后，两组均接受0.5%氟烷。在整个诱导过程中测量动脉压、心率以及血浆去甲肾上腺素和肾上腺素浓度。在第1组，插管与收缩压（相对于诱导前值）升高13%、舒张压升高35%相关，尽管血浆去甲肾上腺素浓度无显著变化。在第2组，尽管对插管有升压反应，但与诱导前值相比，收缩压无总体变化，舒张压仅升高13%。这种反应与去甲肾上腺素浓度升高78%相关；肾上腺素浓度无显著变化。
