Cao Xiaoming, Hu Shike, Zheng Hua, Mukhtar Aiman, Wu KaiMing, Gu Liyuan
School of Nuclear Technology and Chemistry and Biology, Hubei University of Science and Technology, Xianning, People's Republic of China.
The State Key Laboratory of Refractories and Metallurgy, Hubei Province Key Laboratory of Systems Science in Metallurgical Process, International Research Institute for Steel Technology, Collaborative Innovation Center for Advanced Steels, Wuhan University of Science and Technology, Wuhan, People's Republic of China.
Discov Nano. 2023 Oct 31;18(1):136. doi: 10.1186/s11671-023-03916-3.
A facile template method was employed to synthesize Fe nanowires of different sizes, dimensions. Comprehensive analyses were conducted to explore their morphology, structure, composition, and magnetic properties. The surface of as-prepared Fe nanowires was modified with SiO by sol-gel method to improve the dispersion of as-prepared Fe nanowires in aqueous solution. Furthermore, the relaxation properties, biocompatibility and in vivo imaging abilities of the Fe@SiO nanowires were evaluated. The study revealed that the SiO-coated Fe nanowires functioned effectively as transverse relaxation time (T) contrast agents (CAs). Notably, as the length of the Fe@SiO nanowires increased, their diameter decreased, leading to a higher the transverse relaxivity (r) value. Our study identified that among the Fe nanowires synthesized, the Fe3@SiO nanowires, characterized by a diameter of around 30 nm and a length of approximately 500 nm, exhibited the highest r value of 59.3 mM s. These nanowires demonstrated good biocompatibility and non-toxicity. Notably, upon conducting small animal imaging a 1.5 T with Sprague-Dawley rats, we observed a discernible negative enhancement effect in the liver. These findings indicate the promising potential of Fe@SiO nanowires as T CAs, with the possibility of tuning their size for optimized results.
采用一种简便的模板法合成了不同尺寸和维度的铁纳米线。进行了综合分析以探究其形态、结构、组成和磁性。通过溶胶 - 凝胶法用二氧化硅修饰所制备的铁纳米线表面，以改善所制备的铁纳米线在水溶液中的分散性。此外，还评估了Fe@SiO纳米线的弛豫特性、生物相容性和体内成像能力。研究表明，二氧化硅包覆的铁纳米线作为横向弛豫时间（T2）造影剂（CAs）发挥了有效作用。值得注意的是，随着Fe@SiO纳米线长度的增加，其直径减小，导致横向弛豫率（r2）值更高。我们的研究确定，在所合成的铁纳米线中，直径约为30 nm、长度约为500 nm的Fe3@SiO纳米线表现出最高的r2值，为59.3 mM-1 s-1。这些纳米线显示出良好的生物相容性和无毒性。值得注意的是，在用Sprague-Dawley大鼠在1.5 T下进行小动物成像时，我们在肝脏中观察到了明显的负增强效应。这些发现表明Fe@SiO纳米线作为T2 CAs具有广阔的潜力，并且有可能通过调整其尺寸以获得优化结果。
