Northern Theater General Hospital, Shenyang, 110016, China.
Key Laboratory for Anisotropy and Texture of Materials, School of Materials Science and Engineering, Education Ministry of China, Northeastern University, Shenyang, 110819, China.
Biometals. 2024 Apr;37(2):337-355. doi: 10.1007/s10534-023-00551-4. Epub 2023 Oct 31.
Fe was selected as an alloying element for the first time to prepare a new antibacterial titanium alloy based on micro-area potential difference (MAPD) antibacterial mechanism. The microstructure, the corrosion resistance, the mechanical properties, the antibacterial properties and the cell biocompatibility have been investigated in detail by optical microscopy, scanning electron microscopy, electrochemical testing, mechanical property test, plate count method and cell toxicity measurement. It was demonstrated that heat treatment had a significant on the compressive mechanical properties and the antibacterial properties. Ti-xFe (x = 3,5 and 9) alloys after 850 °C/3 h + 550 °C/62 h heat treatment exhibited strong antimicrobial properties with an antibacterial rate of more than 90% due to the MAPD caused by the redistribution of Fe element during the aging process. In addition, the Fe content and the heat treatment process had a significant influence on the mechanical properties of Ti-xFe alloy but had nearly no effect on the corrosion resistance. All Ti-xFe alloys showed non-toxicity to the MC3T3 cell line in comparison with cp-Ti, indicating that the microzone potential difference had no adverse effect on the corrosion resistance, cell proliferation, adhesion, and spreading. Strong antibacterial properties, good cell compatibility and good corrosion resistance demonstrated that Ti-xFe alloy might be a candidate titanium alloy for medical applications.
铁首次被选为合金元素，基于微区电位差（MAPD）抗菌机制，制备了一种新型抗菌钛合金。通过光学显微镜、扫描电子显微镜、电化学测试、力学性能测试、平板计数法和细胞毒性测量，详细研究了其微观结构、耐腐蚀性、力学性能、抗菌性能和细胞生物相容性。结果表明，热处理对压缩力学性能和抗菌性能有显著影响。Ti-xFe（x=3、5 和 9）合金经 850°C/3h+550°C/62h 热处理后，由于时效过程中 Fe 元素重新分布导致 MAPD，表现出很强的抗菌性能，抗菌率超过 90%。此外，Fe 含量和热处理工艺对 Ti-xFe 合金的力学性能有显著影响，但对耐腐蚀性几乎没有影响。与 cp-Ti 相比，所有 Ti-xFe 合金对 MC3T3 细胞系均表现出低毒性，表明微区电位差对耐腐蚀性、细胞增殖、黏附和铺展没有不良影响。良好的耐腐蚀性、良好的细胞相容性和良好的耐腐蚀性表明 Ti-xFe 合金可能是一种有前途的医用钛合金。
