伴弥散性血管内凝血的伯基特淋巴瘤/白血病中的变异易位t(8;22)及15号染色体（q22）和17号染色体（q12 - 21）异常

Variant translocation t(8;22) and abnormalities of chromosome 15(q22) and 17(q12-21) in a Burkitt's lymphoma/leukaemia with disseminated intravascular coagulation.

作者信息

Daly P, Brito-Babapulle V, Lawlor E, Blaney C, Parreira A, Catovsky D

出版信息

Br J Haematol. 1986 Nov;64(3):561-9. doi: 10.1111/j.1365-2141.1986.tb02212.x.

DOI:10.1111/j.1365-2141.1986.tb02212.x

Abstract

Severe disseminated intravascular coagulation was observed in a patient with Burkitt's lymphoma/leukaemia. Immunological studies on leukaemic blasts from relapsed bone marrow revealed a B-cell phenotype (B4+, B1+, HLA-Dr+, J5+) with membrane bound IgM lambda. Cytogenetic investigation revealed a variant Burkitt's translocation t(8;22)(q24;q11) involving the lambda light chain gene region and abnormalities of chromosomes 15 and 17 with breakpoints at q22 and q12 respectively, similar to those observed in the t(15;17) in acute promyelocytic leukaemia. Transmission electron microscopy of the leukaemic blasts showed crystalline cytoplasmic inclusions which may have had a role in precipitating the disseminated intravascular coagulation.

摘要

在一名伯基特淋巴瘤/白血病患者中观察到严重的弥散性血管内凝血。对复发骨髓中的白血病原始细胞进行的免疫学研究显示，其具有B细胞表型（B4 +、B1 +、HLA - Dr +、J5 +），带有膜结合IgMλ。细胞遗传学研究发现了一种变异的伯基特易位t(8;22)(q24;q11)，涉及λ轻链基因区域，以及15号和17号染色体异常，断点分别位于q22和q12，这与急性早幼粒细胞白血病中t(15;17)所观察到的情况相似。白血病原始细胞的透射电子显微镜检查显示有结晶状胞质内含物，这些内含物可能在引发弥散性血管内凝血中起了作用。