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为患有精神疾病的无家可归退伍军人事务部服务使用者开具的苯二氮䓬类药物处方。

Benzodiazepine Prescriptions for Homeless Veterans Affairs Service Users With Mental Illness.

作者信息

Koh Katherine A, Szymkowiak Dorota, Tsai Jack

机构信息

Department of Psychiatry, Massachusetts General Hospital-Harvard Medical School, and Boston Health Care for the Homeless Program, Boston (Koh); National Center on Homelessness Among Veterans, U.S. Department of Veterans Affairs (VA), Tampa, Florida (Szymkowiak, Tsai); School of Public Health, University of Texas Health Science Center at Houston, Houston (Tsai).

出版信息

Psychiatr Serv. 2024 Apr 1;75(4):316-325. doi: 10.1176/appi.ps.20220472. Epub 2023 Oct 31.

Abstract

OBJECTIVE

Despite elevated risk for substance use disorder and overdose death in the homeless population, benzodiazepine prescribing for this population has not been examined. In this study, the authors used data from the U.S. Department of Veterans Affairs (VA) health care system to examine benzodiazepine prescribing and risky and potentially inappropriate benzodiazepine prescribing practices for homeless VA service users.

METHODS

Using national VA administrative data (2018-2019), the authors conducted logistic regression to compare likelihood of benzodiazepine prescribing and t tests to compare indicators of risky and potentially inappropriate benzodiazepine prescribing patterns for homeless service users with mental illness (N=244,113) and their housed peers (N=2,763,513).

RESULTS

Unadjusted analyses showed that benzodiazepines were prescribed for 7.5% of homeless VA service users with mental illness, versus 9.4% of their housed peers (p<0.001). Analyses adjusted for sociodemographic and clinical characteristics and health care utilization showed that homeless service users were less likely than their housed peers to receive a benzodiazepine prescription (AOR=0.70, 99% CI=0.68-0.72). However, compared with their housed peers, homeless service users received higher rates of risky and potentially inappropriate benzodiazepine prescriptions, including multiple concurrent benzodiazepine prescriptions (9.4% vs. 7.0%, p<0.001) and concurrent prescriptions for benzodiazepines and opioids (36.9% vs. 31.2%, p<0.001) or sedatives (61.9% vs. 45.9%, p<0.001).

CONCLUSIONS

Although homeless VA service users with mental illness were less likely than their housed peers to receive a benzodiazepine prescription, benzodiazepine prescriptions for these service users had more characteristics of risky and potentially inappropriate prescribing.

摘要

目的

尽管无家可归人群中物质使用障碍和服药过量死亡风险较高,但针对该人群的苯二氮䓬类药物处方情况尚未得到研究。在本研究中,作者利用美国退伍军人事务部(VA)医疗保健系统的数据,对无家可归的VA服务使用者的苯二氮䓬类药物处方以及危险和潜在不适当的苯二氮䓬类药物处方行为进行了研究。

方法

作者利用VA的全国行政数据(2018 - 2019年),进行逻辑回归以比较开具苯二氮䓬类药物处方的可能性,并进行t检验以比较患有精神疾病的无家可归服务使用者(N = 244,113)及其有住所的同龄人(N = 2,763,513)的危险和潜在不适当苯二氮䓬类药物处方模式指标。

结果

未经调整的分析显示,患有精神疾病的无家可归VA服务使用者中有7.5%开具了苯二氮䓬类药物,而其有住所的同龄人中这一比例为9.4%(p < 0.001)。在对社会人口统计学、临床特征和医疗保健利用情况进行调整后的分析显示,无家可归的服务使用者比其有住所的同龄人获得苯二氮䓬类药物处方的可能性更小(调整后比值比[AOR]=0.70,99%置信区间[CI]=0.68 - 0.72)。然而,与有住所的同龄人相比,无家可归的服务使用者获得危险和潜在不适当苯二氮䓬类药物处方的比例更高,包括多种苯二氮䓬类药物同时处方(9.4%对7.0%,p < 0.001)以及苯二氮䓬类药物与阿片类药物(36.9%对31.2%,p < 0.001)或镇静剂同时处方(61.9%对45.9%,p < 0.001)。

结论

尽管患有精神疾病的无家可归VA服务使用者比其有住所的同龄人获得苯二氮䓬类药物处方的可能性更小,但这些服务使用者的苯二氮䓬类药物处方具有更多危险和潜在不适当处方的特征。

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