Division of Performance and Health, Institute for Sport and Sport Science, TU Dortmund University, Dortmund, Germany.
Department of Nutrition and Movement Sciences, Faculty of Health, Medicine and Life Sciences, Maastricht University, School of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht, the Netherlands.
Eur J Pediatr. 2024 Jan;183(1):379-388. doi: 10.1007/s00431-023-05304-6. Epub 2023 Oct 31.
Endurance training has been shown to be effective in treating adolescents with major depressive disorder (MDD). To integrate endurance training into the therapeutic setting and the adolescents' daily lives, the current performance status of the adolescents should be accurately assessed. This study aims to examine adolescents with MDD concerning exhaustion criteria during a cardiopulmonary exercise test (CPET), as well as to compare the values obtained thereon with sex- and age-related control values. The study included a retrospective examination of exhaustion criteria ((i) oxygen consumption (V̇O) plateau, (ii) peak respiratory exchange ratio (RER) > 1.0, (iii) peak heart rate (HR) ≥ 95% of the age-predicted maximal HR, and (iv) peak blood lactate concentration (BLC) > 8.0 mmol⋅L) during a graded CPET on a cycle ergometer in adolescents with MDD (n = 57). Subsequently, maximal V̇O, peak minute ventilation, V̇O at the first ventilatory threshold, and peak work rate of participants who met at least two of four criteria were compared with published control values using an independent-sample t-test. Thirty-three percent of the total population achieved a V̇O plateau and 75% a RER > 1.0. The HR and BLC criteria were met by 19% and 22%, respectively. T-test results revealed significant differences between adolescents with MDD and control values for all outcomes. Adolescents with MDD achieved between 56% and 83% of control values. Conclusions: The study shows that compared with control values, fewer adolescents with MDD achieve the exhaustion criteria on a CPET and adolescents with MDD have significantly lower cardiorespiratory fitness. Clinical trial registration: No. U1111-1145-1854. What is Known: • It is already known that endurance training has a positive effect on depressive symptoms. What is New: • A relevant proportion of adolescents with major depressive disorder do not achieve their V̇O2max during a graded cardiopulmonary exercise test. • Adolescents with major depressive disorder have significantly lower cardiorespiratory fitness compared to sex- and age-related control values.
耐力训练已被证明对治疗患有重度抑郁症（MDD）的青少年有效。为了将耐力训练融入治疗环境和青少年的日常生活中，需要准确评估青少年当前的身体状态。本研究旨在检查患有 MDD 的青少年在心肺运动测试（CPET）中达到疲劳标准的情况，并将在此获得的值与性别和年龄相关的对照值进行比较。该研究回顾性地检查了患有 MDD 的青少年在功率自行车递增 CPET 中达到的疲劳标准（（i）耗氧量（V̇O）平台，（ii）峰值呼吸交换率（RER）>1.0，（iii）峰值心率（HR）≥最大预测 HR 的 95%，以及（iv）峰值血乳酸浓度（BLC）>8.0mmol·L）（n=57）。随后，使用独立样本 t 检验将满足至少两个标准的参与者的最大 V̇O、峰值分钟通气量、第一通气阈时的 V̇O 和峰值工作率与已发表的对照值进行比较。在总人口中，有 33%达到了 V̇O 平台，有 75%达到了 RER>1.0。HR 和 BLC 标准的满足率分别为 19%和 22%。t 检验结果显示，患有 MDD 的青少年与对照值在所有结果上均存在显著差异。患有 MDD 的青少年达到对照值的 56%至 83%。结论：与对照值相比，患有 MDD 的青少年在 CPET 中达到疲劳标准的比例较低，且患有 MDD 的青少年心肺功能明显较低。临床试验注册号：无。已知情况：• 已有研究表明，耐力训练对抑郁症状有积极影响。新发现：• 患有重度抑郁症的青少年中，有相当一部分在分级心肺运动测试中无法达到其最大摄氧量。• 与性别和年龄相关的对照值相比，患有重度抑郁症的青少年心肺功能明显较低。
