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咔唑合成的趋势——最新进展(2013 - 2023年)

Trends in carbazole synthesis - an update (2013-2023).

作者信息

Allen Lewis A T, Natho Philipp

机构信息

CheMastery, Paper Yard, 11a Quebec Way, London, SE16 7LG, UK.

FLAME-Lab, Flow Chemistry and Microreactor Technology Laboratory, Department of Pharmacy-Drug Sciences, University of Bari "A. Moro", Via E. Orabona 4, 70125 Bari, Italy.

出版信息

Org Biomol Chem. 2023 Nov 22;21(45):8956-8974. doi: 10.1039/d3ob01605f.

Abstract

The interest of scientists in the carbazole core has risen steadily over the last 30 years, particularly over the last decade given its presence in several active pharmaceutical ingredients, functional materials and a wide range of biologically active natural products. The continuous development of more efficient, more (regio-)selective and "greener" methodologies to access the carbazole core is thus imperative. This review compares and evaluates synthetic strategies towards the carbazole core that have been reported since 2013, with a focus on their applicability towards the total synthesis of carbazole-containing natural products.

摘要

在过去30年里,科学家们对咔唑核心结构的兴趣一直在稳步上升,尤其是在过去十年,因为它存在于多种活性药物成分、功能材料以及众多具有生物活性的天然产物中。因此,不断开发更高效、更具(区域)选择性和“更绿色”的方法来构建咔唑核心结构势在必行。本综述比较并评估了自2013年以来报道的构建咔唑核心结构的合成策略,重点关注它们在含咔唑天然产物全合成中的适用性。

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