Kirkland L E, Bradley E L
Biol Reprod. 1986 Oct;35(3):579-86. doi: 10.1095/biolreprod35.3.579.
Radioimmunoassay (RIA) of prolactin in the prairie deermouse was established and validated. Serum samples were taken from reproductively inhibited animals grown in experimental populations and compared with reproductively capable control animals of both sexes. At the time of assay, serum prolactin concentrations was unaffected by the length of time a control female was exposed to the olfactory stimulation of bedding soiled by her mate or the stage of the estrous cycle as indicated by vaginal cytology. The reproductively inhibited males and females had significantly reduced reproductive organ weights, body weights, and serum prolactin concentrations compared with their respective controls. Also, the relative mean adenohypophysial weight was greater in the inhibited males. Several significant correlations between prolactin and various gravimetric measures are reported for both males and females. Possible relationships between prolactin and other endocrine systems are discussed.
建立并验证了草原鹿鼠催乳素的放射免疫分析方法。从实验种群中生长的生殖受抑制动物身上采集血清样本，并与具有生殖能力的雌雄对照动物进行比较。在测定时，血清催乳素浓度不受对照雌性暴露于其配偶弄脏的垫料的嗅觉刺激时间长短或阴道细胞学所指示的发情周期阶段的影响。与各自的对照组相比，生殖受抑制的雄性和雌性的生殖器官重量、体重和血清催乳素浓度显著降低。此外，受抑制雄性的腺垂体相对平均重量更大。报告了雄性和雌性催乳素与各种重量测量指标之间的若干显著相关性。还讨论了催乳素与其他内分泌系统之间可能的关系。
