SubDepartamento de Medicina, Hospital Base de Valdivia, Valdivia, Chile.
Laboratorio de Biología Molecular, Hospital Base de Valdivia, Valdivia, Chile.
Rev Med Chil. 2023 Feb;151(1):23-31. doi: 10.4067/s0034-98872023000100023.
The SARS-CoV-2 pandemic is associated with morbidity, hospitalizations, absenteeism, and mortality among healthcare workers (HCW).
To evaluate the seroconversion rate in HCW exposed to SARS-CoV-2 in the early pandemic phase in 2020 at a regional reference hospital.
One hundred seventy-nine HCW working at a regional hospital were invited to a longitudinal study performed between April-July 2020. A serological analysis by ELISA IgG for viral nucleoprotein and protein S with a secondary analysis by ELISA IgG protein S1/S2 for samples with positive or doubtful result was carried out together with a complementary online survey to inquire about occupational or community exposures to SARS-CoV-2.
Two cases with baseline infection were detected (1.1%, one symptomatic and one asymptomatic) and no cases of seroconversion were detected. During the study period, there were 136 patients hospitalized with COVID-19, and regional weekly COVID-19 incidence ranged from 2.7 to 24.4 per 100,000 inhabitants. No SARS-CoV-2 cases were detected by PCR among 27 HCW who consulted for respiratory symptoms in the period. Online surveys confirmed direct care of COVID-19 patients and also detected a high degree of unprotected social interaction at work.
There was no evidence of seroconversion in this group of HCW exposed to the risk of infection by SARS-CoV-2 during the onset of the COVID-19 pandemic. Personal protective equipment and other measures used by the HCW were extremely useful for their protection in the initial phase of the pandemic.
SARS-CoV-2 大流行与医疗保健工作者（HCW）的发病率、住院率、旷工率和死亡率有关。
评估 2020 年大流行早期在一家区域参考医院接触 SARS-CoV-2 的 HCW 的血清转化率。
邀请 179 名在区域医院工作的 HCW 参加 2020 年 4 月至 7 月进行的纵向研究。通过 ELISA IgG 对病毒核蛋白和蛋白 S 进行血清学分析，并对阳性或可疑结果的样本进行 ELISA IgG 蛋白 S1/S2 二次分析，同时进行在线补充调查，以了解 SARS-CoV-2 的职业或社区暴露情况。
检测到 2 例基线感染（1.1%，1 例有症状，1 例无症状），未检测到血清转化病例。在研究期间，有 136 名 COVID-19 住院患者，区域每周 COVID-19 发病率在每 100,000 居民 2.7 至 24.4 例之间。在呼吸道症状咨询的 27 名 HCW 中，未通过 PCR 检测到 SARS-CoV-2 病例。在线调查证实了对 COVID-19 患者的直接护理，并发现工作中的无保护社交互动程度很高。
在 COVID-19 大流行开始时接触 SARS-CoV-2 感染风险的这群 HCW 中，没有证据表明血清转化。HCW 使用的个人防护设备和其他措施在大流行的初始阶段对他们的保护非常有用。
