Epidemiology Unit, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Reggio Emilia, Italy
Department of Biomedical, Metabolic and Neural Sciences, Centre for Environmental, Nutritional and Genetic Epidemiology (CREAGEN), Public Health Unit, University of Modena and Reggio Emilia, Reggio Emilia, Italy.
BMJ Open. 2023 Oct 31;13(10):e074140. doi: 10.1136/bmjopen-2023-074140.
Despite strong evidence for the efficacy of low-radiation dose CT (LDCT) in reducing lung cancer (LC) mortality, implementing LC screening (LCS) programmes remains a challenge. We aim to systematically review the evidence on the strategies used to recruit the adult population at risk of LC to LDCT within LCS programmes and to estimate the effectiveness of interventions identified, used to reach the potentially eligible population, increase participation and informed choice, and ensure equitable access.
This sequential systematic literature review will consist of three steps: (1) a scoping review of existing strategies and organisational models for LCS; (2) selecting papers reporting relevant outcomes (test coverage, screening participation and informed choice) and comparing results among different models; (3) a systematic review of interventions implemented to increase participation in LCS programmes. Each step will follow the methodological guidelines provided by the Cochrane Collaboration and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Data sources include electronic databases such as Medline (PubMed version), Embase, CINAHL (Ebsco version), Scopus and Cochrane CENTRAL. The search will be limited to studies published from January 2000 to March 2023 in English, Italian, French, Spanish, Serbian and Croatian language. Findings will be synthesised quantitatively and qualitatively as appropriate. Risk of bias assessment will be only applied to studies selected in the second and third steps. The quality of evidence will be summarised for each outcome using the Grading Recommendation Assessment, Development and Evaluation methodology.
Given that this is a review of existing literature, ethics approval is not required. The results will be published in peer-reviewed scientific journals and presented at relevant conferences. The findings of this review will help guide health authorities in organising LCS programmes and developing recommendations, policies, and actions at national and regional levels.
CRD42023408357.
尽管低辐射剂量 CT（LDCT）在降低肺癌（LC）死亡率方面有强有力的证据，但实施 LC 筛查（LCS）计划仍然是一个挑战。我们旨在系统地回顾用于在 LCS 计划中招募有患 LC 风险的成年人群进行 LDCT 的策略的证据，并估计所确定的干预措施的有效性，这些干预措施用于接触潜在合格人群，增加参与度和知情选择，并确保公平获得。
这是一项序贯系统文献综述，将包括三个步骤：（1）对 LCS 的现有策略和组织模型进行范围综述；（2）选择报告相关结果（测试覆盖率、筛查参与和知情选择）的论文，并比较不同模型之间的结果；（3）系统综述为增加 LCS 计划参与度而实施的干预措施。每个步骤都将遵循 Cochrane 合作组织和系统评价和荟萃分析报告的首选项目提供的方法学指南。数据来源包括电子数据库，如 Medline（PubMed 版本）、Embase、CINAHL（Ebsco 版本）、Scopus 和 Cochrane CENTRAL。搜索将限于 2000 年 1 月至 2023 年 3 月期间以英语、意大利语、法语、西班牙语、塞尔维亚语和克罗地亚语发表的研究。结果将根据需要进行定量和定性综合。仅对第二和第三步中选择的研究进行偏倚风险评估。使用推荐评估、制定和评估方法，对每个结果的证据质量进行总结。
由于这是对现有文献的综述，因此不需要伦理批准。研究结果将发表在同行评议的科学期刊上，并在相关会议上展示。本综述的结果将有助于指导卫生当局组织 LCS 计划，并在国家和地区层面制定建议、政策和行动。
PROSPERO 注册号：CRD42023408357。
