Department of Obstetrics and Gynecology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, 528 Zhangheng Road, Shanghai, China.
Sci Rep. 2023 Oct 31;13(1):18708. doi: 10.1038/s41598-023-46005-2.
Studies on the association between depression and self-reported endometriosis are limited, and further studies are required to investigate this association. Data were collected from the National Health and Nutrition Examination Survey database (2005-2006). Based on the inclusion and exclusion criteria, 100 participants with self-reported endometriosis and 1295 participants without self-reported endometriosis were included, representing a total population of 64,989,430. Depression severity was assessed using the Patient Health Questionnaire 9 (PHQ9). A survey-weighted logistic regression analysis was performed to explore the association between depression and endometriosis. Subgroup analyses were conducted to explore heterogeneity. The prevalence of endometriosis was 7.17%. A significant positive association was found between the PHQ9 score and endometriosis. After adjusting for all covariates, the PHQ9 score positively correlated with endometriosis. Furthermore, compared with the participants without depression, those with moderate depression were more prone to have endometriosis both in unadjusted and fully adjusted model. However, the relationship between severe depression and endometriosis was not significant in all models (P > 0.05). Our findings highlight the influence of depression on the prevalence of self-reported endometriosis. Further studies are required to elucidate the causal relationship between depression and self-reported endometriosis.
关于抑郁与自我报告的子宫内膜异位症之间关联的研究有限，需要进一步研究以探讨这种关联。数据来自国家健康和营养检查调查数据库（2005-2006 年）。根据纳入和排除标准，纳入了 100 名自我报告的子宫内膜异位症患者和 1295 名无自我报告的子宫内膜异位症患者，共代表了 64989430 人的总人口。使用患者健康问卷 9 项（PHQ9）评估抑郁严重程度。采用调查加权逻辑回归分析探讨抑郁与子宫内膜异位症之间的关联。进行了亚组分析以探讨异质性。子宫内膜异位症的患病率为 7.17%。PHQ9 评分与子宫内膜异位症之间存在显著正相关。在调整所有协变量后，PHQ9 评分与子宫内膜异位症呈正相关。此外，与无抑郁的参与者相比，在未调整和完全调整的模型中，中度抑郁的参与者更易患子宫内膜异位症。然而，在所有模型中（P>0.05），重度抑郁与子宫内膜异位症之间的关系并不显著。我们的研究结果强调了抑郁对自我报告的子宫内膜异位症患病率的影响。需要进一步研究来阐明抑郁与自我报告的子宫内膜异位症之间的因果关系。
