Marrero Castillo Mariana, Kaufman David, Valdes Camacho Juanita, Bourgoyne Kesler, Jacob John, Amalraj Benedict, Gulati Neerja
Internal Medicine, Ochsner Louisiana State University Health Shreveport - Academic Medical Center, Shreveport, USA.
Allergy and Immunology, Ochsner Louisiana State University Health Shreveport - Academic Medical Center, Shreveport, USA.
Cureus. 2023 Sep 29;15(9):e46199. doi: 10.7759/cureus.46199. eCollection 2023 Sep.
Fixed-drug eruptions (FDEs) are dermatological reactions characterized by specific skin lesions triggered by certain medications. Our case reports commonly used medications that can cause drug-induced skin reactions. Chlorthalidone, a widely used diuretic, had not been prominently linked to FDEs. Here, we present the case of a 45-year-old African-American male who developed classic FDE skin lesions following the initiation of chlorthalidone therapy. This case underscores the imperative for further investigation and heightened awareness among healthcare professionals regarding chlorthalidone-associated FDEs. Findings suggest that such reactions might be more prevalent than previously acknowledged, underscoring the significance of prompt diagnosis and effective management of drug-induced skin responses. Notably, the patient's lesions showed complete resolution upon discontinuing the diuretic, reinforcing the causal relationship. This case is an essential reminder of the importance of vigilance in monitoring patients for adverse drug reactions, even in unlikely medications, such as chlorthalidone..
固定性药疹（FDEs）是一种皮肤病反应，其特征是由某些药物引发特定的皮肤损害。我们的病例报告列举了常用的可引起药物性皮肤反应的药物。氯噻酮是一种广泛使用的利尿剂，此前并未被显著地认为与固定性药疹有关。在此，我们报告一例45岁的非裔美国男性病例，该患者在开始使用氯噻酮治疗后出现了典型的固定性药疹皮肤损害。该病例强调了进一步研究的必要性，以及医疗保健专业人员对氯噻酮相关固定性药疹提高认识的紧迫性。研究结果表明，此类反应可能比之前认为的更为普遍，凸显了及时诊断和有效处理药物性皮肤反应的重要性。值得注意的是，停用利尿剂后患者的皮损完全消退，进一步证实了因果关系。该病例有力地提醒人们，即使对于像氯噻酮这样不太可能引发不良反应的药物，在监测患者药物不良反应时保持警惕也至关重要。
