Institute of Biodiversity, Aquatic Geomicrobiology, Friedrich Schiller University , Jena, Germany.
Electron Microscopy Center, Jena University Hospital , Jena, Germany.
Microbiol Spectr. 2023 Dec 12;11(6):e0086723. doi: 10.1128/spectrum.00867-23. Epub 2023 Nov 1.
Since its discovery, Ln-dependent metabolism in bacteria attracted a lot of attention due to its bio-metallurgical application potential regarding Ln recycling and circular economy. The physiological role of Ln is mostly studied dependent on presence and absence. Comparisons of how different (utilizable) Ln affect metabolism have rarely been done. We noticed unexpectedly pronounced changes in gene expression caused by different Ln supplementation. Our research suggests that strain RH AL1 distinguishes different Ln elements and that the effect of Ln reaches into many aspects of metabolism, for instance, chemotaxis, motility, and polyhydroxyalkanoate metabolism. Our findings regarding Ln accumulation suggest a distinction between individual Ln elements and provide insights relating to intracellular Ln homeostasis. Understanding comprehensively how microbes distinguish and handle different Ln elements is key for turning knowledge into application regarding Ln-centered biometallurgy.
自从镧系元素依赖性代谢在细菌中被发现以来，由于其在镧系元素回收和循环经济方面的生物冶金应用潜力，引起了人们的广泛关注。镧系元素的生理作用主要是通过存在和不存在来研究的。很少有关于不同（可利用的）镧系元素如何影响代谢的比较。我们出人意料地注意到，不同的镧系元素补充会导致基因表达发生明显变化。我们的研究表明，菌株 RH AL1 可以区分不同的镧系元素，而且镧系元素的作用会涉及到代谢的许多方面，例如趋化性、运动性和聚羟基烷酸代谢。我们关于镧系元素积累的发现表明，不同的镧系元素之间存在区别，并为细胞内镧系元素稳态提供了相关见解。全面了解微生物如何区分和处理不同的镧系元素，是将知识转化为以镧系元素为中心的生物冶金应用的关键。
