Hospital Pablo Tobón Uribe, Medellín, Colombia.
Universidad de Antioquia, Medellín, Colombia.
Andes Pediatr. 2023 Jun;94(3):325-332. doi: 10.32641/andespediatr.v94i3.4458.
Lock therapy is useful for preserving indwelling catheters. Few lock therapy studies have been published in Latin America.
To describe the clinical characteristics of pediatric patients using therapeutic and prophylactic lock therapy for six years in a high-complexity hospital in Colombia.
Cross-sectional descriptive study of patients aged < 18 years who received lock therapy. Collected variables included demographic data, clinical characteristics, blood test results, therapeutic interventions, frequency of admission to the pediatric critical care unit, and mortality. Descriptive analysis was performed.
54 patients were included in the study, most of them males, with 67 episodes of therapeutic lock therapy use. The most frequent diagnosis was hematological neoplasm (61%). Among these patients, 88% presented neutropenia while receiving lock therapy. Catheter preservation was achieved in 75% of the cases. Aminoglycosides were the most commonly used antibiotics (38%). Mortality due to catheter-related bacteremia was 6%. Catheter preservation using ethanol solution 70% was achieved in 62% of the patients with prophylactic lock therapy, all of whom had chronic gastrointestinal pathology.
Catheter preservation rates were 75% and 62% in patients with therapeutic and prophylactic lock therapy, respectively, with a higher rate achieved among cancer patients with neutropenia (80%). Aminoglycosides and vancomycin were the most commonly used antibiotics.
描述在哥伦比亚一家高复杂度医院接受治疗和预防锁治疗的儿科患者的临床特征。
对接受锁治疗的年龄<18 岁的患者进行横断面描述性研究。收集的变量包括人口统计学数据、临床特征、血液检查结果、治疗干预措施、儿科重症监护病房入院次数和死亡率。进行描述性分析。
研究纳入 54 例患者，其中大多数为男性，共发生 67 例治疗性锁治疗。最常见的诊断是血液系统恶性肿瘤（61%）。这些患者中有 88%在接受锁治疗时存在中性粒细胞减少症。75%的病例实现了导管保留。最常使用的抗生素是氨基糖苷类（38%）。导管相关性菌血症导致的死亡率为 6%。接受预防性锁治疗的患者中，有 62%使用 70%乙醇溶液实现了导管保留，所有患者均患有慢性胃肠道疾病。
治疗性和预防性锁治疗的导管保留率分别为 75%和 62%，中性粒细胞减少症的癌症患者的保留率更高（80%）。最常使用的抗生素是氨基糖苷类和万古霉素。
