Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California.
Cancer Epidemiol Biomarkers Prev. 2024 Jan 9;33(1):136-142. doi: 10.1158/1055-9965.EPI-23-0860.
Low levels of 6-sulfatoxymelatonin, the primary urinary metabolite of melatonin, have been linked to cancer and cardiometabolic outcomes in White and female populations.
We examined the association between adulthood adiposity and 6-sulfatoxymelatonin levels in a racially and ethnically diverse population. Our study included 4,078 men in the Multiethnic Cohort with adiposity measurements at enrollment (1993-1996) and biomarkers measured in urines collected in 1995 and 2005. Multivariable linear regression models were used to estimate the percent change in 6-sulfatoxymelatonin levels and 95% confidence intervals (CI). Associations were examined separately by racial/ethnic group.
The prevalence of obesity varied by race and ethnicity, from 10% for Japanese American men to 34% for Native Hawaiian men. Compared with men with normal body mass index (BMI), men who were overweight (-7.8%; 95% CI, -11.9 to -3.5%) and obese (-18.1%; 95% CI, -23.2 to -12.6%) had significantly lower 6-sulfatoxymelatonin levels adjusting for potential confounding factors. Increasing weight gain in adulthood was also associated with lower 6-sulfatoxymelatonin (Ptrend < 0.0001). The inverse associations for BMI and weight change were qualitatively similar across racial and ethnic groups.
Obesity is inversely associated with melatonin in a racially diverse population. This finding is relevant given higher rates of obesity among Black, Native Hawaiian, and Latino men, as well as potential racial and ethnic differences in circadian function.
Melatonin may be a relevant biomarker among obesity-associated malignancies and could shed light on a potential mechanism of cancer disparities.
在白人和女性人群中，褪黑素的主要尿代谢产物 6-硫酸褪黑素水平较低与癌症和心脏代谢结局有关。
我们在一个种族和民族多样化的人群中研究了成年期肥胖与 6-硫酸褪黑素水平之间的关系。我们的研究包括了多民族队列中的 4078 名男性，他们在招募时（1993-1996 年）进行了肥胖测量，并在 1995 年和 2005 年收集的尿液中测量了生物标志物。使用多变量线性回归模型来估计 6-硫酸褪黑素水平的百分比变化及其 95%置信区间（CI）。按种族/民族群体分别检查关联。
肥胖的患病率因种族和民族而异，从日本裔美国男性的 10%到夏威夷原住民男性的 34%不等。与正常体重指数（BMI）的男性相比，超重（-7.8%；95%CI，-11.9 至-3.5%）和肥胖（-18.1%；95%CI，-23.2 至-12.6%）的男性 6-硫酸褪黑素水平显著降低，调整了潜在的混杂因素。成年后体重增加与 6-硫酸褪黑素水平降低也呈相关（Ptrend<0.0001）。BMI 和体重变化的负相关在不同种族和民族群体中具有相似的定性特征。
肥胖与种族多样化人群中的褪黑素呈负相关。鉴于黑种人、夏威夷原住民和拉丁裔男性的肥胖率较高，以及昼夜节律功能的潜在种族和民族差异，这一发现具有相关性。
褪黑素可能是肥胖相关恶性肿瘤的一个相关生物标志物，并可能揭示癌症差异的潜在机制。
