Gnadt J W, Pegram G V
Brain Res. 1986 Oct 1;384(1):29-41. doi: 10.1016/0006-8993(86)91216-3.
Injection of carbachol into the brainstem of rats produced an increase in rapid eye movement (REM) sleep which was site- and dose-dependent. Effective locations for carbachol to stimulate REM sleep included the pontine reticular formation at the level of the trigeminal motor nucleus and the dorsal parabrachial area in the caudal midbrain. The carbachol effect in the caudal pons was dose-dependent. Additionally, this effect was blocked by concomitant administration of the muscarinic antagonist atropine. Control experiments suggested that the drug-induced phenomenon appeared to be an increase in normal physiological REM sleep.
向大鼠脑干注射卡巴胆碱可使快速眼动（REM）睡眠增加，且这种增加具有部位和剂量依赖性。卡巴胆碱刺激REM睡眠的有效部位包括三叉神经运动核水平的脑桥网状结构和尾侧中脑的背侧臂旁区。卡巴胆碱在尾侧脑桥的作用具有剂量依赖性。此外，这种作用可被同时给予的毒蕈碱拮抗剂阿托品阻断。对照实验表明，药物诱导的现象似乎是正常生理性REM睡眠的增加。
