Colhoun E H, Myles L A, Rylett R J
Can J Neurol Sci. 1986 Nov;13(4 Suppl):517-20. doi: 10.1017/s0317167100037239.
Deficiencies in cholinergic nerve function have been clearly documented in patients with Alzheimer's disease. The lack of this neurotransmitter may be responsible for early memory loss in patients with the disease. Choline mustard Az ion has been used in our laboratory to produce cholinergic hypofunction in rat brain. Injections of the compound into the medial septal nucleus and dorsal hippocampus produced tissue lesions. The lesions were dose and time-dependent. Lesions produced in the medial septum resulted in transmitter depression in the hippocampus. These results suggest non-specific tissue damage because 5-HT levels were lower than normal. Other strategies for getting choline mustard Az ion into rat brain are being investigated to circumvent the apparent ability of this compound and other nitrogen mustard analogs of choline to produce non-specific tissue damage when injected directly into brain tissue.
阿尔茨海默病患者胆碱能神经功能缺陷已得到明确记录。这种神经递质的缺乏可能是该疾病患者早期记忆丧失的原因。在我们实验室中，已使用胆碱氮芥Az离子在大鼠脑中产生胆碱能功能减退。将该化合物注射到内侧隔核和背侧海马中会产生组织损伤。这些损伤具有剂量和时间依赖性。在内侧隔区产生的损伤导致海马中的递质减少。这些结果提示存在非特异性组织损伤，因为5-羟色胺水平低于正常。正在研究将胆碱氮芥Az离子导入大鼠脑内的其他方法，以避免该化合物及胆碱的其他氮芥类似物直接注射到脑组织中时产生非特异性组织损伤的明显能力。
