Morgan A R, Garbo G M, Kreimer-Birnbaum M, Keck R W, Chaudhuri K, Selman S H
Cancer Res. 1987 Jan 15;47(2):496-8.
Purpurin derivatives, a group of synthetic photosensitizers, were tested for their photodynamic activity against transplantable N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide-induced urothelial tumors growing in male Fischer 344 rats. Histological examination of tumors in animals treated with the purpurin derivatives and red light (greater than 590 nm, 360 joules/cm2) revealed tumor cell necrosis 24 h after completion of therapy. Control tumors showed no histological change. Purpurins have a major absorption peak in the red region (greater than 650 nm) of the visible spectrum, a region with good tissue penetration, and purpurins can be synthesized with a high degree of purity. This study demonstrates the potential of purpurin derivatives as photosensitizers for photodynamic cancer therapy.
紫红素衍生物是一类合成光敏剂，针对移植于雄性Fischer 344大鼠体内、由N-[4-(5-硝基-2-呋喃基)-2-噻唑基]甲酰胺诱导产生的膀胱上皮肿瘤，对其光动力活性进行了测试。在用紫红素衍生物及红光（大于590 nm，360焦耳/平方厘米）处理的动物中，对肿瘤进行组织学检查发现，治疗结束24小时后肿瘤细胞出现坏死。对照肿瘤未显示组织学变化。紫红素在可见光谱的红色区域（大于650 nm）有一个主要吸收峰，该区域具有良好的组织穿透性，并且紫红素能够以高纯度合成。本研究证明了紫红素衍生物作为光动力癌症治疗光敏剂的潜力。
