Pastrnák A, Jansa P, Kolár Z
Cesk Patol. 1986 Nov;22(4):210-3.
Changing numbers of mast cells were observed in precancerous and cancerous lesions of the gut in mice treated by 1, 2-dimethylhydrazine dihydrochloride. The study included 18 samples of abnormal and atypical epithelium, 14 samples of preinvasive carcinoma, 15 samples of infiltrative carcinoma, and 12 control samples from untreated mice. Carcinogenesis was accompanied by a significant increase of mast cell numbers culminating in preinvasive carcinoma. A decrease of mast cells followed in fully developed adenocarcinomas up to numbers comparable to but more variable than those found in abnormal and atypical epithelium.
在用二盐酸1,2 - 二甲基肼处理的小鼠肠道癌前病变和癌性病变中，观察到肥大细胞数量的变化。该研究包括18个异常和非典型上皮样本、14个浸润前癌样本、15个浸润性癌样本以及12个来自未处理小鼠的对照样本。致癌过程伴随着肥大细胞数量的显著增加，在浸润前癌时达到高峰。在完全发展的腺癌中，肥大细胞数量减少，直至与异常和非典型上皮中的数量相当，但变化更大。
