Zaniboni A, Zambruni A, Marpicati P, Gorni F, Simoncini E, Ragni F, Marini G
Chemioterapia. 1986 Oct;5(5):347-50.
Eighteen patients with measurable advanced colorectal cancer and four with metastatic gastric cancer were treated with cisplatin 100 mg/m2 day 1 and 5-fluorouracil (5-FU) 1000 mg/m2 administered over 6 h i.v. infusion from days 2 to 5 every 21 to 28 days. Five out of 15 fully evaluable patients with colorectal cancer experienced a partial response (33%) while amongst the three evaluable patients with gastric cancer one complete and one partial remission were achieved. Both hematological and non-hematological side-effects were mild. Our preliminary results seem quite interesting and deserve further evaluation.
18例可测量的晚期结直肠癌患者和4例转移性胃癌患者接受了顺铂治疗，剂量为100mg/m²，第1天给药；5-氟尿嘧啶（5-FU）剂量为1000mg/m²，从第2天至第5天通过静脉输注6小时给药，每21至28天为一个周期。15例可全面评估的结直肠癌患者中有5例出现部分缓解（33%），而3例可评估的胃癌患者中，有1例完全缓解，1例部分缓解。血液学和非血液学副作用均较轻。我们的初步结果似乎很有趣，值得进一步评估。
