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Demographic characteristics of participants in clinical trials to treat Alzheimer disease, 2008-2023.

作者信息

Zhang Audrey D, Anderson Timothy S, Hastings S Nicole

机构信息

Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.

Division of General Internal Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.

出版信息

J Am Geriatr Soc. 2024 Mar;72(3):942-945. doi: 10.1111/jgs.18645. Epub 2023 Nov 2.

DOI:10.1111/jgs.18645
PMID:37916640
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10949061/
Abstract
摘要

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本文引用的文献

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What the Aducanumab Approval Reveals About Alzheimer Disease Research.阿杜卡努单抗获批对阿尔茨海默病研究的启示
JAMA Neurol. 2021 Nov 1;78(11):1305-1306. doi: 10.1001/jamaneurol.2021.3404.
2
Representativeness of Participants Eligible to Be Enrolled in Clinical Trials of Aducanumab for Alzheimer Disease Compared With Medicare Beneficiaries With Alzheimer Disease and Mild Cognitive Impairment.与患有阿尔茨海默病和轻度认知障碍的医疗保险受益人群相比，有资格参加阿杜卡奴单抗治疗阿尔茨海默病临床试验的参与者的代表性。
JAMA. 2021 Oct 26;326(16):1627-1629. doi: 10.1001/jama.2021.15286.
3
Disparities by Race and Ethnicity Among Adults Recruited for a Preclinical Alzheimer Disease Trial.成年人参与临床前阿尔茨海默病试验的种族和民族差异。
JAMA Netw Open. 2021 Jul 1;4(7):e2114364. doi: 10.1001/jamanetworkopen.2021.14364.
4
Participation of Women and Older Participants in Randomized Clinical Trials of Lipid-Lowering Therapies: A Systematic Review.女性和老年参与者参与降脂治疗随机临床试验的情况：系统评价。
JAMA Netw Open. 2020 May 1;3(5):e205202. doi: 10.1001/jamanetworkopen.2020.5202.
5
Enrollment of Older Patients, Women, and Racial/Ethnic Minority Groups in Contemporary Acute Coronary Syndrome Clinical Trials: A Systematic Review.当代急性冠状动脉综合征临床试验中老年患者、女性和种族/少数民族群体的入组情况：一项系统评价。
JAMA Cardiol. 2020 Jun 1;5(6):714-722. doi: 10.1001/jamacardio.2020.0359.
6
Representativeness of Randomized Clinical Trial Cohorts in End-stage Kidney Disease: A Meta-analysis.终末期肾病随机临床试验队列的代表性：一项荟萃分析。
JAMA Intern Med. 2019 Oct 1;179(10):1316-1324. doi: 10.1001/jamainternmed.2019.1501.
7
Strategies addressing barriers to clinical trial enrollment of underrepresented populations: a systematic review.解决代表性不足人群临床试验入组障碍的策略：一项系统综述
Contemp Clin Trials. 2014 Nov;39(2):169-82. doi: 10.1016/j.cct.2014.08.004. Epub 2014 Aug 15.
8
Participation of women and sex analyses in late-phase clinical trials of new molecular entity drugs and biologics approved by the FDA in 2007-2009.2007-2009 年 FDA 批准的新分子实体药物和生物制品的后期临床试验中女性参与情况和性别分析。
J Womens Health (Larchmt). 2013 Jul;22(7):604-16. doi: 10.1089/jwh.2012.3753. Epub 2013 Jun 14.
9
Examining the evidence: a systematic review of the inclusion and analysis of older adults in randomized controlled trials.审视证据：一项关于纳入和分析老年人群体的随机对照试验的系统评价。
J Gen Intern Med. 2011 Jul;26(7):783-90. doi: 10.1007/s11606-010-1629-x. Epub 2011 Feb 1.