Analysis of the Changes and Significance of Serum APN, MCP-1, hs-CRP, SOD Levels in Patients with Hypertension Combined with Diabetes Mellitus.

OBJECTIVE

The objective of this study was to observe and analyze changes in serum levels of APN, MCP-1, hs-CRP, and SOD in patients with hypertension and diabetes mellitus (DM) and to investigate the correlations among these inflammatory factors. The study aimed to provide insights into disease monitoring and management.

METHODS

320 cases were included in this study, including 50 cases in group A (simple diabetes mellitus); 60 cases in group B (simple hypertension); and 90 cases in group C (Hypertension with diabetes). 120 healthy subjects served as the control group. Fasting blood glucose (FPG), glycosylated hemoglobin (GHbA1c) and other biochemical indicators were detected, and ELISA detected the levels of MCP-1, APN and SOD, hs-CRP was detected by immunoenhanced turbidimetric method.

RESULTS

Patients with diabetes (group A), hypertension (group B), and hypertension with diabetes (group C) exhibited elevated FPG, GHbA1c, hs-CRP, and MCP-1 levels and decreased APN and SOD levels compared to the control group (P < .05). In patients with hypertension and diabetes (group C), FPG and GHbA1c levels were positively correlated with MCP-1 and hs-CRP, while APN levels showed a negative correlation with these inflammatory markers(P < .05). SOD levels were positively correlated with MCP-1, APN, and hs-CRP levels in group C patients (P < .05).

CONCLUSION

These results suggest that APN, MCP-1, hs-CRP, and SOD are important factors in the development of atherosclerosis in patients with comorbid hypertension and diabetes. Monitoring these biomarkers may guide disease management strategies.