He Qinghua, Dong Min, Pan Qi, Wang Xiaoxia, Guo Lixin
Department of Endocrinology, Beijing Hospital, National Center of Gerontology, Beijing, China.
Department of Endocrinology, Beijing Hospital, National Center of Gerontology, Beijing, China -
Minerva Endocrinol. 2019 Sep;44(3):252-258. doi: 10.23736/S0391-1977.18.02822-5. Epub 2018 Apr 24.
We aimed to analyze the relationship between the combination with hypertension and the level of inflammatory cytokines in peripheral serum in patients with type 2 diabetes mellitus (DM), and to explore the value of inflammatory cytokines in predicting type 2 DM combined with hypertension.
A total of 120 patients diagnosed with type 2 DM in our hospital from March 2014 to September 2016 were selected. The clinical data were retrospectively analyzed. These patients were divided into the combination with hypertension group (N.=56) and the non-combination with hypertension group (N.=64), including 75 males and 45 females.
Duration of DM, fasting plasma glucose (FPG), glycosylated hemoglobin A1c (HbA1c) and also levels of inflammatory cytokines (hs-CRP, TNF-α and IL-6) in the combination with hypertension group were all significantly higher than those in the non-combination with hypertension group (P<0.05). The incidence rate of hypertension in patients with high-level hs-CRP, high-level TNF-α and high-level IL-6 were significantly higher than that in patients with normal levels (P<0.05). Type 2 DM patients with high-level inflammatory cytokines had significantly longer duration of DM, and higher FPG and HbA1c values than those with normal levels (P<0.05). Results also showed that hs-CRP, TNF-α and IL-6 were positively correlated with FPG, HbA1c and the hypertension grade, and FPG and HbA1c were also positively correlated with the hypertension grade.Logistic regression analysis revealed that hs-CRP, TNF-α, IL-6, the duration of DM, BMI, FPG, HbA1c, TC and LDL had independent values in predicting Type 2 DM combined with hypertension (P<0.05).
Levels of serum hs-CRP, TNF-α and IL-6 are significantly elevated in patients with type 2 DM combined with essential hypertension, which are important factors affecting changes in blood glucose. The higher the level of inflammatory cytokines is, the higher the grade of hypertension will be.
我们旨在分析2型糖尿病（DM）患者合并高血压与外周血清中炎性细胞因子水平之间的关系，并探讨炎性细胞因子在预测2型DM合并高血压中的价值。
选取2014年3月至2016年9月在我院确诊为2型DM的120例患者。对其临床资料进行回顾性分析。这些患者被分为合并高血压组（n = 56）和未合并高血压组（n = 64），其中男性75例，女性45例。
合并高血压组的DM病程、空腹血糖（FPG）、糖化血红蛋白A1c（HbA1c）以及炎性细胞因子（hs-CRP、TNF-α和IL-6）水平均显著高于未合并高血压组（P < 0.05）。hs-CRP高水平、TNF-α高水平和IL-6高水平患者的高血压发病率显著高于正常水平患者（P < 0.05）。炎性细胞因子高水平的2型DM患者的DM病程显著更长，FPG和HbA1c值也高于正常水平患者（P < 0.05）。结果还显示，hs-CRP、TNF-α和IL-6与FPG、HbA1c及高血压分级呈正相关，FPG和HbA1c也与高血压分级呈正相关。Logistic回归分析显示，hs-CRP、TNF-α、IL-6、DM病程、BMI、FPG、HbA1c、总胆固醇（TC）和低密度脂蛋白（LDL）在预测2型DM合并高血压方面具有独立价值（P < 0.05）。
2型DM合并原发性高血压患者血清hs-CRP、TNF-α和IL-6水平显著升高，这些是影响血糖变化的重要因素。炎性细胞因子水平越高，高血压分级越高。
