2型糖尿病患者炎症细胞因子变化与合并高血压之间的相关性

Correlation between changes in inflammatory cytokines and the combination with hypertension in patients with type 2 diabetes mellitus.

作者信息

He Qinghua, Dong Min, Pan Qi, Wang Xiaoxia, Guo Lixin

机构信息

Department of Endocrinology, Beijing Hospital, National Center of Gerontology, Beijing, China.

Department of Endocrinology, Beijing Hospital, National Center of Gerontology, Beijing, China -

出版信息

Minerva Endocrinol. 2019 Sep;44(3):252-258. doi: 10.23736/S0391-1977.18.02822-5. Epub 2018 Apr 24.

DOI:10.23736/S0391-1977.18.02822-5

PMID:29687969

Abstract

BACKGROUND

We aimed to analyze the relationship between the combination with hypertension and the level of inflammatory cytokines in peripheral serum in patients with type 2 diabetes mellitus (DM), and to explore the value of inflammatory cytokines in predicting type 2 DM combined with hypertension.

METHODS

A total of 120 patients diagnosed with type 2 DM in our hospital from March 2014 to September 2016 were selected. The clinical data were retrospectively analyzed. These patients were divided into the combination with hypertension group (N.=56) and the non-combination with hypertension group (N.=64), including 75 males and 45 females.

RESULTS

Duration of DM, fasting plasma glucose (FPG), glycosylated hemoglobin A1c (HbA1c) and also levels of inflammatory cytokines (hs-CRP, TNF-α and IL-6) in the combination with hypertension group were all significantly higher than those in the non-combination with hypertension group (P<0.05). The incidence rate of hypertension in patients with high-level hs-CRP, high-level TNF-α and high-level IL-6 were significantly higher than that in patients with normal levels (P<0.05). Type 2 DM patients with high-level inflammatory cytokines had significantly longer duration of DM, and higher FPG and HbA1c values than those with normal levels (P<0.05). Results also showed that hs-CRP, TNF-α and IL-6 were positively correlated with FPG, HbA1c and the hypertension grade, and FPG and HbA1c were also positively correlated with the hypertension grade.Logistic regression analysis revealed that hs-CRP, TNF-α, IL-6, the duration of DM, BMI, FPG, HbA1c, TC and LDL had independent values in predicting Type 2 DM combined with hypertension (P<0.05).

CONCLUSIONS

Levels of serum hs-CRP, TNF-α and IL-6 are significantly elevated in patients with type 2 DM combined with essential hypertension, which are important factors affecting changes in blood glucose. The higher the level of inflammatory cytokines is, the higher the grade of hypertension will be.

摘要

背景

我们旨在分析2型糖尿病（DM）患者合并高血压与外周血清中炎性细胞因子水平之间的关系，并探讨炎性细胞因子在预测2型DM合并高血压中的价值。

方法

选取2014年3月至2016年9月在我院确诊为2型DM的120例患者。对其临床资料进行回顾性分析。这些患者被分为合并高血压组（n = 56）和未合并高血压组（n = 64），其中男性75例，女性45例。

结果

合并高血压组的DM病程、空腹血糖（FPG）、糖化血红蛋白A1c（HbA1c）以及炎性细胞因子（hs-CRP、TNF-α和IL-6）水平均显著高于未合并高血压组（P < 0.05）。hs-CRP高水平、TNF-α高水平和IL-6高水平患者的高血压发病率显著高于正常水平患者（P < 0.05）。炎性细胞因子高水平的2型DM患者的DM病程显著更长，FPG和HbA1c值也高于正常水平患者（P < 0.05）。结果还显示，hs-CRP、TNF-α和IL-6与FPG、HbA1c及高血压分级呈正相关，FPG和HbA1c也与高血压分级呈正相关。Logistic回归分析显示，hs-CRP、TNF-α、IL-6、DM病程、BMI、FPG、HbA1c、总胆固醇（TC）和低密度脂蛋白（LDL）在预测2型DM合并高血压方面具有独立价值（P < 0.05）。