Liu Lei, Lin Chen, Li Xiu, Cheng Yulan, Wang Rui, Luo Chao, Zhao Xinyuan, Jiang Zhitao
Department of Pathology, Affiliated Hospital of Nantong University, Nantong, China.
Vectors and Parasitosis Control and Prevention Section, Center of Disease Prevention and Control in Pudong New Area of Shanghai, Shanghai, China.
Evid Based Complement Alternat Med. 2023 Oct 25;2023:4559802. doi: 10.1155/2023/4559802. eCollection 2023.
Kidney stone disease induces chronic renal insufficiency by crystal-induced renal tubular epithelial cell injury. It has been reported that the prevalence of kidney stone disease is increasing, accompanied by the high recurrence rate. Alkaline mineral water has been reported to possess beneficial effects to attenuate inflammation. Here, we explored the potential protective effects and underlying mechanisms of alkaline mineral water against calcium oxalate-induced kidney injury.
We performed the mice kidney stone model by administering glyoxylate at 100 mg/kg once daily for 7 days. To assess the effects of alkaline mineral water on oxalate-induced kidney injury, mice drank different water (distilled water, natural mineral water at pH = 8.0, as well as natural mineral water at pH = 9.3) for 7 days, respectively, followed by glyoxylate exposure. After collection, crystal formation, kidney injury and cell apoptosis, fibrosis, oxidative stress, as well as inflammation were measured.
Our results showed that glyoxylate treatment led to kidney crystal formation and fibrosis, which can be attenuated by drinking alkaline mineral water. Furthermore, alkaline mineral water also reduced kidney injury and cell apoptosis, oxidative stress, and inflammation.
Alkaline mineral water supplement prevents progression of glyoxylate-induced kidney stones through alleviating oxidative stress and inflammation.
肾结石病通过晶体诱导的肾小管上皮细胞损伤导致慢性肾功能不全。据报道，肾结石病的患病率正在上升，且复发率很高。据报道，碱性矿泉水具有减轻炎症的有益作用。在此，我们探讨了碱性矿泉水对草酸钙诱导的肾损伤的潜在保护作用及其潜在机制。
我们通过每天一次给予100mg/kg乙醛酸，连续7天建立小鼠肾结石模型。为了评估碱性矿泉水对草酸诱导的肾损伤的影响，小鼠分别饮用不同的水（蒸馏水、pH = 8.0的天然矿泉水以及pH = 9.3的天然矿泉水）7天，然后进行乙醛酸暴露。收集样本后，检测晶体形成、肾损伤、细胞凋亡、纤维化、氧化应激以及炎症情况。
我们的结果表明，乙醛酸处理导致肾晶体形成和纤维化，而饮用碱性矿泉水可减轻这种情况。此外，碱性矿泉水还减少了肾损伤、细胞凋亡、氧化应激和炎症。
补充碱性矿泉水可通过减轻氧化应激和炎症来预防乙醛酸诱导的肾结石进展。
