Department of Ophthalmology, Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Hunan Clinical Research Center of Ophthalmic Disease, Changsha, Hunan, China.
J Glob Health. 2023 Nov 3;13:04132. doi: 10.7189/jogh.13.04132.
Various epidemiological studies have focused on the adverse health outcomes of meteorological factors. However, there has been little research on the impact of humidex on allergic conjunctivitis, especially in child and adolescent populations. We aimed to explore the impact of humidex, a comprehensive index of relative humidity and temperature, on child and adolescent allergic conjunctivitis admissions.
Outpatient visit data for allergic conjunctivitis, meteorological factors and air pollutants in Shanghai for the 2017-2022 period were retrieved. For the purpose of analysing the nonlinear connection and lag impact between humidex and admissions for paediatric and adolescent allergic conjunctivitis, the distributed lag nonlinear model (DLNM) was fitted.
A total of 147 090 cases were included in our cohort. We found a significantly nonlinear effect on humidex and allergic conjunctivitis. In the single-day lag pattern, the relative risks (RR) of allergic conjunctivitis were significant at lag 0 (RR = 1.08, 95% confidence interval (CI) = 1.05-1.11) to lag 2 (RR = 1.01, 95% CI = 1.00-1.01), lag 5 (RR = 1.01, 95% CI = 1.00-1.01) to lag 9 (RR = 1.01, 95% CI = 1.00-1.01), and lag 14 (RR = 1.02, 95% CI: 1.01-1.03). In the cumulative-lag day pattern, the RR of allergic conjunctivitis were significant at lag 0-0 (RR = 1.08, 95% CI = 1.05-1.11) to lag 0-14 (RR = 1.21, 95% CI = 1.13-1.28). We found that boys, children aged 7-17 years, and children in the warm season were more vulnerable to humidex. In addition, the highest attributable fraction (AF) and attributable number (AN) of humidex are at lag 0-14 (AF = 0.17, AN = 25 026).
Humidex exposure markedly increased the risk of allergic conjunctivitis, especially in highly high humidex. Appropriate public health management is needed for disease management and early intervention.
多项流行病学研究关注气象因素对健康的不良影响。然而，关于湿热指数对过敏性结膜炎的影响，尤其是在儿童和青少年人群中的研究较少。我们旨在探讨湿热指数（相对湿度和温度的综合指标）对儿童和青少年过敏性结膜炎入院的影响。
检索了 2017 年至 2022 年期间上海的过敏性结膜炎门诊就诊数据、气象因素和空气污染物数据。为了分析湿热指数与儿童和青少年过敏性结膜炎入院之间的非线性关联和滞后影响，我们拟合了分布滞后非线性模型（DLNM）。
我们的队列共纳入了 147090 例病例。我们发现湿热指数与过敏性结膜炎之间存在显著的非线性关系。在单日滞后模式下，过敏性结膜炎的相对风险（RR）在滞后 0 天（RR=1.08，95%置信区间（CI）=1.05-1.11）至滞后 2 天（RR=1.01，95%CI=1.00-1.01）、滞后 5 天（RR=1.01，95%CI=1.00-1.01）至滞后 9 天（RR=1.01，95%CI=1.00-1.01）和滞后 14 天（RR=1.02，95%CI=1.01-1.03）均具有统计学意义。在累积滞后天数模式下，滞后 0-0 天（RR=1.08，95%CI=1.05-1.11）至滞后 0-14 天（RR=1.21，95%CI=1.13-1.28）的 RR 也具有统计学意义。我们发现男孩、7-17 岁的儿童和温暖季节的儿童更容易受到湿热指数的影响。此外，湿热指数的最高归因分数（AF）和归因数量（AN）在滞后 0-14 天（AF=0.17，AN=25026）最高。
暴露于湿热指数会显著增加过敏性结膜炎的风险，尤其是在高湿热指数时。需要采取适当的公共卫生管理措施来进行疾病管理和早期干预。
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