中国青岛湿度指数暴露与精神分裂症入院率的关联：一项时间序列研究。

Association of Exposure to Humidex with Schizophrenia Admissions in Qingdao, China: A Time-Series Study.

作者信息

Han Haibin, Liu Jie, Wang Lu, Li Gen, Wang Tingting

机构信息

Department of Psychiatry, Qingdao Mental Health Center, Qingdao, Shandong, People's Republic of China.

Department of Spinal Surgery, Qingdao Huangdao Central Hospital, Qingdao, Shandong, People's Republic of China.

出版信息

Neuropsychiatr Dis Treat. 2025 Apr 29;21:989-997. doi: 10.2147/NDT.S521191. eCollection 2025.

DOI:10.2147/NDT.S521191

PMID:40322724

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12049671/

Abstract

PURPOSE

This study aimed to quantify the effects of humidex (a composite index of temperature and relative humidity) on schizophrenia admissions.

METHODS

The exposure-lag-response relationship between humidex and schizophrenia admissions was explored via a distributed lag nonlinear model (DLNM). The modification effects of sex and age were also investigated. We further calculated the attributable fraction (AF) and number (AN) due to humidex.

RESULTS

During the study period, the median humidex in Qingdao was 15.22, and the low humidex (-7, 2.5th percentile) and high humidex (40, 97.5th percentile) were -7 and 40, respectively. The significant adverse effects of low humidex on schizophrenia admissions persisted from lag 2 [Relative risk (RR)=1.060, 95% CI (confidence interval): 1.006-1.117] to lag 5 (1.063, 1.008-1.122) and reached its maximum at lag 4 (1.078, 1.008-1.152). Females and young individuals are susceptible to low humidex. In addition, the AFs and ANs of schizophrenia admissions due to low humidex were 7.2% and 407, respectively.

CONCLUSION

Schizophrenia admission was associated with only low humidex. Humidex may serve as an early warning indicator of schizophrenia.

摘要

目的

本研究旨在量化体感温度（温度与相对湿度的综合指数）对精神分裂症入院率的影响。

方法

通过分布滞后非线性模型（DLNM）探讨体感温度与精神分裂症入院率之间的暴露-滞后-反应关系。还研究了性别和年龄的修正效应。我们进一步计算了由体感温度导致的归因分数（AF）和归因数（AN）。

结果

研究期间，青岛的体感温度中位数为15.22，低温感温度（-7，第2.5百分位数）和高温感温度（40，第97.5百分位数）分别为-7和40。低温感温度对精神分裂症入院率的显著不良影响从滞后2 [相对风险（RR）=1.060，95%置信区间（CI）：1.006 - 1.117]持续到滞后5（1.063，1.008 - 1.122），并在滞后4达到最大值（1.078，1.008 - 1.152）。女性和年轻人对低温感温度敏感。此外，因低温感温度导致的精神分裂症入院率的归因分数和归因数分别为7.2%和407。