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一种具有多功能 ADP-核糖基化活性的核糖基化 NAD。

A ribose-functionalized NAD with versatile activity for ADP-ribosylation.

机构信息

Department of Pharmacology and Pharmaceutical Sciences, Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences, University of Southern California, Los Angeles, CA 90089, USA.

Titus Family Department of Clinical Pharmacy, Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences, University of Southern California, Los Angeles, CA 90089, USA.

出版信息

Chem Commun (Camb). 2023 Nov 21;59(93):13843-13846. doi: 10.1039/d3cc04343f.

DOI:10.1039/d3cc04343f
PMID:37921487
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10841986/
Abstract

An NAD featuring an adenosyl 4'-azido functions as a general substrate for poly-ADP-ribose polymerases. Its derived mono- and poly-ADP-ribosylated proteins can be adequately recognized by distinct ADP-ribosylation-specific readers. This molecule represents the first ribose-functionalized NAD with versatile activities across different ADP-ribosyltransferases and provides insight into developing new probes for ADP-ribosylation.

摘要

一种带有腺嘌呤基 4'-叠氮化物的 NAD 可以作为多聚 ADP-核糖聚合酶的通用底物。其衍生的单聚和多聚 ADP-核糖基化蛋白可以被不同的 ADP-核糖基化特异性阅读器充分识别。这种分子是第一个具有多种活性的核糖基化 NAD，可作用于不同的 ADP-核糖基转移酶，并为开发新的 ADP-核糖基化探针提供了思路。

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