中国接受胰岛素治疗的 1 型糖尿病或 2 型糖尿病患者低血糖发生率及危险因素。
Incidence rate and risk factors for hypoglycemia among individuals with type 1 diabetes or type 2 diabetes in China receiving insulin treatment.
机构信息
Department of Endocrinology and Metabolism, Shanghai Jiao Tong University School of Medicine Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center of Diabetes, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Key Clinical Center for Metabolic Disease, Shanghai 200233, China.
Department of Endocrinology and Metabolism, Shanghai Jiao Tong University School of Medicine Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center of Diabetes, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Key Clinical Center for Metabolic Disease, Shanghai 200233, China.
出版信息
Diabetes Res Clin Pract. 2023 Dec;206:110987. doi: 10.1016/j.diabres.2023.110987. Epub 2023 Nov 3.
AIMS
We investigated the real-world incidence of hypoglycemic events among patients with type 1 or type 2 diabetes (T1DM or T2DM) receiving insulin in routine clinical practice in China.
METHODS
In this observational study, data were collected electronically via the Lilly Connected Care Program (LCCP) electronic system from adults with T1DM or T2DM who had registered on LCCP between 1 February 2019 and 31 January 2022, had used insulin for a full 12-week period following registration. The following outcomes were assessed during the 12 weeks following registration: incidence of level 1 and level 2 hypoglycemia.
RESULTS
In total, 22,752 patients were enrolled. Among patients with monitoring data, over the 12-week study period, level 1 and 2 hypoglycemia were experienced by 48.8% and 25.9% of patients with T1DM and 26.5% and 13.9% of patients with T2DM. The proportion of patients treated with oral anti-diabetes drugs (OADs) capable of producing hypoglycemia (sulfonylurea or glinide) was 1.3% in T1DM and 1.6% in T2DM, respectively. Questionnaire data revealed that up to 92.5% of hypoglycemic events occurred outside of hospital and 18.6% were serious.
CONCLUSIONS
These real-world data collected from Chinese patients with diabetes receiving insulin treatment reveal a relatively high percentage of patients experiencing hypoglycemia, with around one quarter of these events classified as severe and as many as 92.5% occurring outside of a hospital or clinic.
目的
我们在中国的常规临床实践中调查了接受胰岛素治疗的 1 型或 2 型糖尿病（T1DM 或 T2DM）患者的低血糖事件实际发生率。
方法
在这项观察性研究中，通过 Lilly Connected Care Program（LCCP）电子系统从 2019 年 2 月 1 日至 2022 年 1 月 31 日期间在 LCCP 上注册的 1 型或 2 型糖尿病成年患者中电子收集数据，这些患者在注册后使用胰岛素治疗了整整 12 周。在注册后的 12 周内评估了以下结果：1 级和 2 级低血糖的发生率。
结果
共有 22752 名患者入组。在有监测数据的患者中，在 12 周的研究期间，1 型糖尿病患者中有 48.8%和 25.9%经历了 1 级和 2 级低血糖，2 型糖尿病患者中有 26.5%和 13.9%经历了 1 级和 2 级低血糖。有能力引起低血糖（磺脲类或格列奈类）的口服抗糖尿病药物（OAD）治疗的患者比例在 1 型糖尿病中分别为 1.3%，在 2 型糖尿病中分别为 1.6%。问卷调查数据显示，高达 92.5%的低血糖事件发生在医院外，18.6%为严重事件。
结论
这些从接受胰岛素治疗的中国糖尿病患者中收集的真实数据显示，经历低血糖的患者比例相对较高，其中约四分之一的事件被归类为严重事件，多达 92.5%的事件发生在医院或诊所之外。
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