Lin Qingxia, Zhou Dongdong, Cheng Yifan, Wu Chunxue, Deng Binbin
Department of Psychiatry, Wenzhou Medical University First Affiliated Hospital, Wenzhou Medical University, Wenzhou, China.
Mental Health Center, University-Town Hospital of Chongqing Medical University, Chongqing, China.
Gerontology. 2024;70(2):115-124. doi: 10.1159/000534768. Epub 2023 Nov 3.
Previous studies have suggested that the D-dimer to fibrinogen ratio (DD/Fg) could be a potential predictor for deep vein thrombosis, pulmonary embolism, and stroke severity. However, the association between plasma DD/Fg and functional outcome following acute ischemic stroke (AIS) has been unclear.
Our study followed the STROBE guideline and used a prospective cohort design to investigate this association. A total of 454 patients with AIS were enrolled consecutively in our study, and the National Institute of Health Stroke Scale (NIHSS) and modified Rankin Scale (mRS) were assessed for stroke severity and functional outcome, respectively.
We found a significant difference in DD/Fg values between the three groups based on NIHSS scores at admission. Specifically, the DD/Fg values were higher in the poor functional outcome group (mRS score of 2-6) compared to the favorable functional outcome group (mRS score of 0-1) at the 1-year follow-up (p < 0.001). Additionally, the DD/Fg values were independently associated with poor functional prognosis at 1 year following the onset of stroke, even after adjusting for potential confounders (OR 9.21, 95% CI, 3.68-23.02, p < 0.001).
Our findings suggest that DD/Fg values at admission may serve as risk predictors for poor functional outcomes in patients with AIS 1 year after the stroke.
先前的研究表明，D - 二聚体与纤维蛋白原比值（DD/Fg）可能是深静脉血栓形成、肺栓塞和中风严重程度的潜在预测指标。然而，急性缺血性中风（AIS）后血浆DD/Fg与功能结局之间的关联尚不清楚。
我们的研究遵循STROBE指南，采用前瞻性队列设计来研究这种关联。共有454例AIS患者连续纳入我们的研究，分别使用美国国立卫生研究院卒中量表（NIHSS）和改良Rankin量表（mRS）评估中风严重程度和功能结局。
我们发现，根据入院时的NIHSS评分，三组之间的DD/Fg值存在显著差异。具体而言，在1年随访时，功能结局较差组（mRS评分为2 - 6）的DD/Fg值高于功能结局良好组（mRS评分为0 - 1）（p < 0.001）。此外，即使在调整潜在混杂因素后，DD/Fg值仍与中风发病后1年的功能预后不良独立相关（OR 9.21，95% CI，3.68 - 23.02，p < 0.001）。
我们的研究结果表明，入院时的DD/Fg值可能作为AIS患者中风后1年功能结局不良的风险预测指标。
