Department of Otolaryngology-Head and Neck Surgery, Taichung Armed Forces General Hospital, Taichung, Taiwan, Republic of China.
Department of Otolaryngology-Head and Neck Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China.
Int J Med Sci. 2023 Oct 2;20(13):1671-1678. doi: 10.7150/ijms.86769. eCollection 2023.
Histamine receptor-1 (H) antagonists like levocetirizine are frequently used nowadays to treat rhinitis patients who experience rhinorrhea and sneezing. The trachea may be affected by the H antagonist when it is used to treat nasal symptoms, either orally or through inhalation. The purpose of this study was to ascertain in vitro effects of levocetirizine on isolated tracheal smooth muscle. As a parasympathetic mimetic, methacholine (10 M) causes contractions in tracheal smooth muscle, which is how we tested effectiveness of levocetirizine on isolated rat tracheal smooth muscle. We also tested the drug's impact on electrically induced tracheal smooth muscle contractions. The impact of menthol (either before or after) on the contraction brought on by 10 M methacholine was also investigated. According to the results, the addition of levocetirizine at concentrations of 10 M or more caused a slight relaxation in response to methacholine's 10 M contraction. Levocetirizine could prevent spike contraction brought on by electrical field stimulation (EFS). As the concentration rose, it alone had a neglect effect on the trachea's basal tension. Before menthol was applied, levocetirizine might have also inhibited the function of the cold receptor. According to this study, levocetirizine might potentially impede the parasympathetic function of the trachea. If levocetirizine was used prior to menthol addition, it also reduced the function of cold receptors.
组胺受体-1（H）拮抗剂，如左西替利嗪，如今常用于治疗出现流涕和打喷嚏的鼻炎患者。当 H 拮抗剂用于治疗鼻症状时，无论是口服还是吸入，都可能会影响气管。本研究旨在确定左西替利嗪对离体气管平滑肌的体外作用。作为一种拟副交感神经药物，乙酰甲胆碱（10M）可引起气管平滑肌收缩，我们以此来测试左西替利嗪对离体大鼠气管平滑肌的作用。我们还测试了该药物对电诱导气管平滑肌收缩的影响。我们还研究了薄荷醇（在乙酰甲胆碱之前或之后）对 10M 乙酰甲胆碱引起的收缩的影响。结果表明，左西替利嗪在 10M 或更高浓度下可轻微松弛 10M 乙酰甲胆碱引起的收缩。左西替利嗪可以预防电场刺激（EFS）引起的尖峰收缩。随着浓度的升高，它对气管的基础张力单独产生了忽视效应。在应用薄荷醇之前，左西替利嗪可能还抑制了冷受体的功能。根据这项研究，左西替利嗪可能潜在地阻碍气管的副交感神经功能。如果在加入薄荷醇之前使用左西替利嗪，它还降低了冷受体的功能。
