Department of Health Services Management, College of Public Health and Health Informatics, Umm Al-Qura University, Makkah, Saudi Arabia.
Saudi J Kidney Dis Transpl. 2022 Jul-Aug;33(4):526-534. doi: 10.4103/1319-2442.388187.
Patients with end-stage kidney disease (ESKD) are required to take multiple medications. Adherence to a complex regimen of medications is challenging and might lead to non-adherence. This study aimed to assess nonadherence to prescribed medications among patients with ESKD in Makkah City and determine the factors associated with a such behavior. A cross-sectional study was conducted at three governmental hospitals in Makkah City, Saudi Arabia. Descriptive statistics were performed to characterize participants, and a multivariable logistic regression analysis was used to determine factors associated with nonadherence to prescribed medications among patients with ESKD. In total, 358 patients have submitted completed surveys and were included in this study. A considerable number (45.25%) of participating patients were found to be nonadherent to prescribed medications. The factors: age, belief that taking medications as scheduled is important, adherence to dialysis sessions, and the number of comorbid diseases had significant and negative associations with nonadherence to prescribed medications. On the other hand, the factors: forgetfulness and having depression were significantly and positively associated with non-adherence to prescribed medications. Non-adherence to medications among patients on hemodialysis is a significant issue that leads to life-threatening complications. The factors identified as being significantly associated with nonadherence should be considered in designing future interventions to improve adherence to medications.
患有终末期肾病（ESKD）的患者需要服用多种药物。坚持服用复杂的药物方案具有挑战性，可能导致不遵医嘱。本研究旨在评估麦加市 ESKD 患者对规定药物的不依从性，并确定与这种行为相关的因素。在沙特阿拉伯麦加市的三家政府医院进行了横断面研究。采用描述性统计方法对参与者进行特征描述，并采用多变量逻辑回归分析确定与 ESKD 患者不遵医嘱相关的因素。共有 358 名患者提交了完整的调查问卷，并纳入本研究。研究发现，相当数量（45.25%）的参与患者不遵守规定的药物治疗方案。有以下因素与不遵医嘱显著相关：年龄、认为按时服药很重要、遵守透析治疗、以及共病数量。另一方面，有两个因素与不遵医嘱显著相关：健忘和抑郁。血液透析患者不遵医嘱是一个严重的问题，会导致危及生命的并发症。在设计提高药物依从性的未来干预措施时，应考虑与不依从相关的这些显著因素。
