Department of Teaching and Learning, Vanderbilt University, Nashville, Tennessee, USA.
Department of Psychology, Vanderbilt University, Nashville, Tennessee, USA.
Dev Neuropsychol. 2023 Oct 3;48(7):335-346. doi: 10.1080/87565641.2023.2276950. Epub 2023 Nov 14.
Prader-Willi Syndrome (PWS) is characterized by hyperphagia, an extreme and persistent hunger that emerges in early childhood. We used event-related potentials (ERPs) to objectively investigate brain responses to low- and high-calorie foods, animals, and household objects in 20 satiated adolescents with PWS. Late Positive Potential (LPP) responses to food images did not differ from non-food images. Rather, we observed larger ERPs to high-calorie foods relative to animal images () in an earlier time window. These responses correlated with greater severity of hyperphagia (). Thus, hyperphagia associated with PWS may be due to altered satiety regulation rather than increased motivational salience.
普拉德-威利综合征（PWS）的特征是食欲过盛，即一种出现在儿童早期的极度和持续的饥饿感。我们使用事件相关电位（ERPs）客观地研究了 20 名饱腹感青少年对低热量和高热量食物、动物和家庭用品的大脑反应。对食物图像的晚期正波（LPP）反应与非食物图像没有区别。相反，我们观察到在较早的时间窗口中，高热量食物相对于动物图像的 ERPs 更大（）。这些反应与食欲过盛的严重程度呈正相关（）。因此，与 PWS 相关的食欲过盛可能是由于饱腹感调节的改变，而不是动机显著性的增加。
