褪黑素扰乱了瘤胃微生物群落结构和代谢途径。

College of Animal Science and Technology, Yangzhou University , Yangzhou, China.

State Key Laboratory of Sheep Genetic Improvement and Healthy Production, Xinjiang Academy of Agricultural Reclamation Sciences , Shihezi, China.

Microbiol Spectr. 2023 Dec 12;11(6):e0032723. doi: 10.1128/spectrum.00327-23. Epub 2023 Nov 6.

In studies, it has been found that the effects of MLT on rumen microorganisms and metabolites can change the rumen flora structure, significantly inhibit the relative abundance of harmful and improve the relative abundance of beneficial bacteria. MLT may regulate the "arginine-glutathione" pathway, "phenylalanine, tyrosine and tryptophan biosynthesis-tryptophan generation" branch, "tryptophan-kynurenine" metabolism, and "tryptophan-tryptamine-serotonin" pathway through microorganisms.

研究发现，褪黑素对瘤胃微生物及其代谢物的影响可改变瘤胃菌群结构，显著抑制有害菌的相对丰度，提高有益菌的相对丰度。褪黑素可能通过微生物调控“精氨酸-谷胱甘肽”途径、“苯丙氨酸、酪氨酸和色氨酸生物合成-色氨酸生成”分支、“色氨酸-犬尿氨酸”代谢和“色氨酸-色胺-血清素”途径。