• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

N-糖基化酶对乙烯基DNA加合物的修复

Repair of etheno DNA adducts by N-glycosylases.

作者信息

Oesch F, Adler S, Rettelbach R, Doerjer G

出版信息

IARC Sci Publ. 1986(70):373-9.

PMID:3793186
Abstract

After incubation of chloroacetaldehyde-treated DNA with cell-free homogenates, the excision of N2,3-ethenoguanine and 1,N6-ethenoadenine was observed with a rat brain tumour cell line. The repair mechanism was that of an N-glycosylase. The high specificity of all known DNA N-glycosylases and some unique properties of the enzymatic reaction indicate the existence of N-glycosylases specific for the repair of etheno, or similar, adducts.

摘要

用无细胞匀浆孵育经氯乙醛处理的DNA后，在大鼠脑肿瘤细胞系中观察到N2,3-乙烯基鸟嘌呤和1,N6-乙烯基腺嘌呤的切除。修复机制是N-糖基化酶的机制。所有已知DNA N-糖基化酶的高特异性以及酶促反应的一些独特性质表明存在对乙烯基或类似加合物修复具有特异性的N-糖基化酶。

相似文献

1
Repair of etheno DNA adducts by N-glycosylases.N-糖基化酶对乙烯基DNA加合物的修复
IARC Sci Publ. 1986(70):373-9.
2
Enzymology of the repair of etheno adducts in mammalian cells and in Escherichia coli.哺乳动物细胞和大肠杆菌中乙烯基加合物修复的酶学
IARC Sci Publ. 1999(150):249-61.
3
All four known cyclic adducts formed in DNA by the vinyl chloride metabolite chloroacetaldehyde are released by a human DNA glycosylase.氯乙烯代谢产物氯乙醛在DNA中形成的所有四种已知环状加合物都由一种人类DNA糖基化酶释放出来。
Proc Natl Acad Sci U S A. 1994 Feb 1;91(3):1024-8. doi: 10.1073/pnas.91.3.1024.
4
Release of N2,3-ethenoguanine from chloroacetaldehyde-treated DNA by Escherichia coli 3-methyladenine DNA glycosylase II.大肠杆菌3-甲基腺嘌呤DNA糖基化酶II从氯乙醛处理的DNA中释放N2,3-乙烯基鸟嘌呤
Proc Natl Acad Sci U S A. 1992 Oct 1;89(19):9331-4. doi: 10.1073/pnas.89.19.9331.
5
MutY catalytic core, mutant and bound adenine structures define specificity for DNA repair enzyme superfamily.MutY催化核心、突变体及结合腺嘌呤的结构决定了DNA修复酶超家族的特异性。
Nat Struct Biol. 1998 Dec;5(12):1058-64. doi: 10.1038/4168.
6
Specific interaction of wild-type and truncated mouse N-methylpurine-DNA glycosylase with ethenoadenine-containing DNA.野生型和截短型小鼠N-甲基嘌呤-DNA糖基化酶与含乙烯腺嘌呤的DNA的特异性相互作用。
Biochemistry. 1998 Jan 13;37(2):580-9. doi: 10.1021/bi972313l.
7
In vivo repair of methylation damage in Aag 3-methyladenine DNA glycosylase null mouse cells.Aag 3-甲基腺嘌呤DNA糖基化酶缺陷型小鼠细胞中甲基化损伤的体内修复
Nucleic Acids Res. 2000 Sep 1;28(17):3294-300. doi: 10.1093/nar/28.17.3294.
8
Single-turnover and pre-steady-state kinetics of the reaction of the adenine glycosylase MutY with mismatch-containing DNA substrates.腺嘌呤糖基化酶MutY与含错配DNA底物反应的单轮和稳态前动力学
Biochemistry. 1998 Oct 20;37(42):14756-64. doi: 10.1021/bi981594+.
9
Enzymology of repair of etheno-adducts.乙烯基加合物修复的酶学
Mutat Res. 2003 Oct 29;531(1-2):219-29. doi: 10.1016/j.mrfmmm.2003.07.008.
10
Both purified human 1,N6-ethenoadenine-binding protein and purified human 3-methyladenine-DNA glycosylase act on 1,N6-ethenoadenine and 3-methyladenine.纯化的人 1,N6-乙烯腺嘌呤结合蛋白和纯化的人 3-甲基腺嘌呤-DNA 糖基化酶均可作用于 1,N6-乙烯腺嘌呤和 3-甲基腺嘌呤。
Proc Natl Acad Sci U S A. 1992 Oct 15;89(20):9386-90. doi: 10.1073/pnas.89.20.9386.

引用本文的文献

1
Etheno adducts: from tRNA modifications to DNA adducts and back to miscoding ribonucleotides.乙烯基加合物：从转运核糖核酸修饰到DNA加合物，再回到错配核糖核苷酸。
Genes Environ. 2021 Jun 16;43(1):24. doi: 10.1186/s41021-021-00199-x.
2
Regulation of NEIL1 protein abundance by RAD9 is important for efficient base excision repair.RAD9对NEIL1蛋白丰度的调节对于高效碱基切除修复很重要。
Nucleic Acids Res. 2015 May 19;43(9):4531-46. doi: 10.1093/nar/gkv327. Epub 2015 Apr 14.
3
Sensitivity of human type II topoisomerases to DNA damage: stimulation of enzyme-mediated DNA cleavage by abasic, oxidized and alkylated lesions.
人类II型拓扑异构酶对DNA损伤的敏感性：无碱基、氧化和烷基化损伤对酶介导的DNA切割的刺激作用。
Nucleic Acids Res. 2000 May 1;28(9):1947-54. doi: 10.1093/nar/28.9.1947.