Berkeley Public Health, University of California, Berkeley, California, USA
Division of Research, Kaiser Permanente, Oakland, California, USA.
BMJ Open. 2023 Nov 6;13(11):e072957. doi: 10.1136/bmjopen-2023-072957.
The National Heart, Lung and Blood Institute Growth and Health Study (NGHS) prospectively collected anthropometric, biospecimens, clinical, health behaviour and psychosocial measures associated with cardiovascular disease from childhood to young adulthood. The aim of the current study was to assess the impact of stress, dysregulated eating and social genomic biomarkers on cardiometabolic risk factors among the original participants now in midlife and their children.
Beginning in 1987-1988, NGHS recruited black and white girls (age 9-10 years) from socioeconomically diverse backgrounds from from three sites: Cincinnati, Ohio; Washington, DC; and Western Contra Costa County, California (N=2379) and followed them for 10 years. The study maintained an 89% retention rate. The current study is 30 years after the start of the original study and focused on the participants of California (n=887) and their children aged 2-17 years. We re-enrolled 624 of 852 eligible participants (73%): 49.2% black and 50.8% white. The mean age was 39.5 years. Among the 645 eligible biological children, 553 were enrolled; 49% black and 51% white, with 51.5% girls and 48.5% boys. The mean age was 9.3 years.
Longitudinal analysis of adolescent drive for thinness predicted higher scores for drive for thinness during midlife, which was indirectly associated with greater adult body mass index through adult drive for thinness. Latent trajectory modelling of adolescent growth over 10 years found that women with persistently high weight trajectory had twice the odds of having children who met the definition for obesity compared with the persistently normal group, adjusting for adult weight.
New studies on neighbourhood socioeconomic status, food insecurity and additional biomarkers of chronic stress, microbiome and accelerated ageing (ie, telomere length and epigenetic clock) are underway. We are developing a 10-year follow-up to understand changes in ageing biomarkers of the participants and their children.
NCT00005132.
国家心肺血液研究所生长与健康研究（NGHS）前瞻性地收集了与心血管疾病相关的人体测量学、生物样本、临床、健康行为和社会心理测量数据，这些数据来自儿童期到成年早期的参与者。本研究的目的是评估压力、饮食失调和社会基因组生物标志物对中年参与者及其子女中年人群中心血管代谢危险因素的影响。
NGHS 于 1987-1988 年从社会经济背景多样化的三个地点（俄亥俄州辛辛那提、华盛顿特区和加利福尼亚州西康特拉科斯塔县）招募了黑人女孩和白人女孩（年龄 9-10 岁）（N=2379），并对其进行了 10 年的随访。该研究保持了 89%的保留率。本研究是在原始研究开始 30 年后进行的，重点关注加利福尼亚州的参与者（n=887）及其 2-17 岁的子女。我们重新招募了 852 名符合条件的参与者中的 624 名（73%）：49.2%为黑人，50.8%为白人。参与者的平均年龄为 39.5 岁。在 645 名符合条件的生物学子女中，有 553 名子女参加了研究；49%为黑人，51%为白人，其中 51.5%为女孩，48.5%为男孩。参与者的平均年龄为 9.3 岁。
青少年对苗条身材的追求的纵向分析预测了中年时期对苗条身材的追求得分更高，这通过成年人对苗条身材的追求间接与成年人的体重指数更高相关。对青少年 10 年体重增长的潜在轨迹建模发现，与持续正常体重组相比，体重持续较高的女性，其孩子符合肥胖定义的可能性是后者的两倍，调整了成年人的体重。
正在进行关于社区社会经济地位、粮食不安全以及慢性应激、微生物组和加速衰老（即端粒长度和表观遗传时钟）的额外生物标志物的新研究。我们正在进行一项为期 10 年的随访，以了解参与者及其子女衰老生物标志物的变化。
NCT00005132。
