2'-取代的螯合菌素类似物的合成及其抗菌活性
Synthesis and antibacterial activity of 2'-substituted chelocardin analogues.
作者信息
Garmaise D L, Chu D T, Bernstein E, Inaba M, Stamm J M
出版信息
J Med Chem. 1979 May;22(5):559-64. doi: 10.1021/jm00191a018.
PMID:379332
Abstract
Chelocardin (1) was condensed with numerous hydrazines, hydrazides, and anilines, yielding 2'-substituted derivatives with antibacterial spectra similar to the parent antibiotic. The hydrazone derivatives 9 and 10 and the two anilino derivatives 42 and 44 had more in vivo antibacterial activity than chelocardin.
摘要
Chelocardin（1）与多种肼、酰肼和苯胺缩合，生成了2'-取代衍生物，其抗菌谱与母体抗生素相似。腙衍生物9和10以及两种苯胺衍生物42和44的体内抗菌活性比Chelocardin更高。
Zotero 插件