Division of Oral and Craniofacial Health Sciences, University of North Carolina at Chapel Hill Adams School of Dentistry , Chapel Hill, North Carolina, USA.
Department of Microbiology and Immunology, University of North Carolina at Chapel Hill School of Medicine , Chapel Hill, North Carolina, USA.
Microbiol Spectr. 2023 Dec 12;11(6):e0229923. doi: 10.1128/spectrum.02299-23. Epub 2023 Nov 7.
Individuals with diabetes are prone to more frequent and severe infections, with many of these infections being polymicrobial. Polymicrobial infections are frequently observed in skin infections and in individuals with cystic fibrosis, as well as in indwelling device infections. Two bacteria frequently co-isolated from infections are and . Several studies have examined the interactions between these microorganisms. The majority of these studies use model systems that cannot accurately replicate the microenvironment of diabetic infections. We employed a novel murine indwelling device model to examine interactions between and . Our data show that competition between these bacteria results in reduced growth in a normal infection. In a diabetic infection, we observe increased growth of both microbes and more severe infection as both bacteria invade surrounding tissues. Our results demonstrate that diabetes changes the interaction between bacteria resulting in poor infection outcomes.
糖尿病患者更容易发生更频繁和更严重的感染，其中许多感染是多种微生物感染。多种微生物感染常发生于皮肤感染和囊性纤维化患者，以及留置装置感染。两种经常从感染中共同分离出来的细菌是 和 。有几项研究检查了这些微生物之间的相互作用。这些研究中的大多数使用 模型系统，这些系统不能准确复制糖尿病感染的微环境。我们采用了一种新的小鼠留置装置模型来研究 和 之间的相互作用。我们的数据表明，这两种细菌之间的竞争导致正常感染中的生长减少。在糖尿病感染中，我们观察到两种微生物的生长增加，并且由于两种细菌侵入周围组织，感染更加严重。我们的结果表明，糖尿病改变了细菌之间的相互作用，导致感染结果不佳。
