Drukker A, Pomeranz A, Reichenberg J, Mor J, Stankiewicz H
Isr J Med Sci. 1986 Nov;22(11):779-82.
The outcome of acute poststreptococcal glomerulonephritis (APSGN) is still controversial. Whereas many studies show a good prognosis, particularly in children, late morphologic and functional renal abnormalities have been described. To verify this latter finding, we evaluated the sodium handling of the kidney several years after APSGN. Eleven subjects (9 children and adolescents and 2 adults) were studied 2 to 3 years after APSGN. At the time of the study all patients were well, without pathologic urinary findings and with normal blood pressures. Five healthy subjects (3 adults and 2 children) served as controls. Following two control periods of 30 min, an i.v. saline load (2.5% NaCl, 1 l/1.73 m2 body surface area) was administered over 45 min. Sodium excretion was measured during the control and salt-loading periods, and during four additional 30-min collection periods. No exaggerated natriuresis was found. We therefore conclude that epidemic APSGN in Israel carries not only an excellent clinical but also a good renal functional prognosis.
急性链球菌感染后肾小球肾炎（APSGN）的预后仍存在争议。尽管许多研究显示预后良好，尤其是在儿童中，但也有关于后期肾脏形态和功能异常的描述。为了验证后一项发现，我们在APSGN发生数年之后评估了肾脏对钠的处理情况。对11名受试者（9名儿童和青少年以及2名成年人）在患APSGN后2至3年进行了研究。在研究时，所有患者情况良好，无病理性尿液检查结果且血压正常。5名健康受试者（3名成年人和2名儿童）作为对照。经过两个30分钟的对照期后，在45分钟内静脉输注生理盐水负荷（2.5%氯化钠，1升/1.73平方米体表面积）。在对照期和盐负荷期以及另外四个30分钟的收集期测量钠排泄量。未发现排钠过多的情况。因此我们得出结论，以色列的流行性APSGN不仅临床预后良好，而且肾功能预后也良好。
