Department of Psychology, Faculty of Philosophy, University of Novi Sad, Novi Sad 21 000, Serbia.
Department of Psychology, Faculty of Philosophy, University of Belgrade, Belgrade 11 000, Serbia.
J Public Health (Oxf). 2024 Feb 23;46(1):e15-e22. doi: 10.1093/pubmed/fdad204.
The Patient Health Questionnaire (PHQ-9) score ≥ 10 balances best sensitivity and specificity when detecting probable depression in patients. In the general population, different cut-offs are suggested. European studies on general populations validating the PHQ-9 against a diagnostic interview to detect depression are rare.
This was a cross-sectional observational epidemiological survey using multistage household probabilistic sampling to recruit a representative adult sample (N = 1203; age = 43.7 ± 13.6; 48.7% male). Mental disorders including current major depressive episode (MDE) were observer-rated (Mini International Neuropsychiatric Interview). The PHQ-9, quality of life (QoL), and loneliness were self-assessed. We performed validity and reliability tests of the PHQ-9 and receiver operating curve (ROC) analysis.
The Serbian PHQ-9 was internally consistent and correlated in the expected directions with QoL and loneliness. At the cut-off score ≥ 8, sensitivity was .85 and specificity was .91. ROC analysis showed that the area under the curve was .95, indicating that the Serbian PHQ-9 can discriminate very well between persons with/without MDE.
When the PHQ-9 is assessed against the structured diagnostic interview in the general population to detect depression, the cut-off of ≥8 balances best sensitivity and specificity.
当用于检测患者中可能存在的抑郁症时,患者健康问卷(PHQ-9)得分≥10 在灵敏度和特异性方面达到最佳平衡。在普通人群中,建议使用不同的截断值。在普通人群中针对抑郁症进行诊断访谈验证 PHQ-9 的欧洲研究很少。
这是一项使用多阶段家庭概率抽样招募代表性成年样本(N=1203;年龄=43.7±13.6;48.7%为男性)的横断面观察性流行病学调查。包括当前主要抑郁发作(MDE)在内的精神障碍由观察者(Mini 国际神经精神访谈)进行评定。PHQ-9、生活质量(QoL)和孤独感由自我评估。我们对 PHQ-9 进行了有效性和可靠性测试,并进行了接收器操作曲线(ROC)分析。
塞尔维亚的 PHQ-9 具有内部一致性,并与 QoL 和孤独感呈预期方向相关。在截断值≥8 时,灵敏度为 0.85,特异性为 0.91。ROC 分析表明曲线下面积为 0.95,表明塞尔维亚 PHQ-9 可以很好地区分有/无 MDE 的人群。
当在普通人群中使用结构化诊断访谈评估 PHQ-9 以检测抑郁症时,截断值≥8 可达到最佳的灵敏度和特异性平衡。