Han Zaiqi, Feng Xiangqing, Du Haifeng
Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
University of Chinese Academy of Sciences, Beijing 100049, China.
J Org Chem. 2023 Nov 17;88(22):16038-16042. doi: 10.1021/acs.joc.3c02031. Epub 2023 Nov 7.
In this paper, we demonstrate a metal-free asymmetric hydrogenation of acyclic α,β-unsaturated ketones under the catalysis of a frustrated Lewis pair (FLP) comprising chiral oxazoline and achiral borane. A wide range of optically active α-substituted ketones were furnished in high yields with 26-85% ee's.
在本文中，我们展示了在手性恶唑啉和非手性硼烷组成的受阻路易斯酸碱对（FLP）催化下，无金属的非环状α,β-不饱和酮的不对称氢化反应。一系列光学活性的α-取代酮以高产率得到，对映体过量值为26%-85%。
