Tuo Y R, Zhang M F
Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
Zhonghua Yan Ke Za Zhi. 2023 Nov 11;59(11):954-959. doi: 10.3760/cma.j.cn112142-20230717-00004.
Primary vitreoretinal lymphoma (PVRL), the most prevalent intraocular lymphoma, is a subtype of primary central nervous system lymphoma (PCNSL) that often clinically mimics uveitis. It is a rare intraocular malignancy characterized by a dismal prognosis. The gold standard for PVRL diagnosis remains cytopathological examination. Additionally, auxiliary tests, such as clonal detection of tumor cells and cytokine analysis, have been employed. Moreover, recent years have witnessed the gradual development of novel molecular biomarkers and detection techniques. To optimize diagnostic strategies for PVRL patients, a comprehensive approach that integrates clinical manifestations, cytological examination, immunological assessment, and molecular biology analysis is indispensable. This article provides a comprehensive review of recent advancements in the diagnosis of primary vitreoretinal lymphoma.
原发性玻璃体视网膜淋巴瘤（PVRL）是最常见的眼内淋巴瘤，是原发性中枢神经系统淋巴瘤（PCNSL）的一种亚型，临床上常表现为葡萄膜炎。它是一种罕见的眼内恶性肿瘤，预后较差。PVRL诊断的金标准仍然是细胞病理学检查。此外，还采用了辅助检测方法，如肿瘤细胞的克隆检测和细胞因子分析。而且，近年来新型分子生物标志物和检测技术也在逐步发展。为优化PVRL患者的诊断策略，综合临床表现、细胞学检查、免疫学评估和分子生物学分析的全面方法必不可少。本文全面综述了原发性玻璃体视网膜淋巴瘤诊断方面的最新进展。
