• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

藏红花酸通过调节代谢、CYP4A11/PPARγ 和 TGF-β/Smad 通路改善糖尿病肾病小鼠模型。

Crocin Ameliorates Diabetic Nephropathy through Regulating Metabolism, CYP4A11/PPARγ, and TGF-β/Smad Pathways in Mice.

机构信息

Department of Endocrinology, Cangzhou Hospital of Integrated Traditional Chinese Medicine and Western Medicine of Hebei Province Affiliated to Hebei University of Chinese Medicine, Cangzhou, China.

Qingxian Branch of Cangzhou Hospital of Integrated Traditional Chinese Medicine and Western Medicine of Hebei Province Affiliated to Hebei University of Chinese Medicine, Cangzhou, China.

出版信息

Curr Drug Metab. 2023;24(10):709-722. doi: 10.2174/0113892002257928231031113337.

DOI:10.2174/0113892002257928231031113337
PMID:37936469
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10825796/
Abstract

INTRODUCTION

Crocin is one of the main components of Crocus sativus L. and can alleviate oxidative stress and inflammation in diabetic nephropathy (DN). However, the specific mechanism by which crocin treats DN still needs to be further elucidated.

METHOD

In the present study, a mouse model of DN was first established to investigate the therapeutic effect of crocin on DN mice. Subsequently, non-targeted metabolomics techniques were used to analyze the mechanisms of action of crocin in the treatment of DN. The effects of crocin on CYP4A11/PPARγ and TGF-β/Smad pathway were also investigated.

RESULT

Results showed that crocin exhibited significant therapeutic and anti-inflammatory, and anti-oxidative effects on DN mice. In addition, the non-targeted metabolomics results indicated that crocin treatment affected several metabolites in kidney. These metabolites were mainly associated with biotin metabolism, riboflavin metabolism, and arachidonic acid metabolism. Furthermore, crocin treatment upregulated the decreased levels of CYP4A11 and phosphorylated PPARγ, and reduced the increased levels of TGF-β1 and phosphorylated Smad2/3 in the kidneys of DN mice.

CONCLUSION

In conclusion, our study validated the considerable therapeutic, anti-inflammatory, and antioxidative impacts of crocin on DN mice. The mechanism of crocin treatment may be related to the regulation of biotin riboflavin and arachidonic acid metabolism, the activation of CYP4A11/PPARγ pathway, and the inhibition of TGF-β/Smad pathway in the kidney.

摘要

简介

藏红花苷是藏红花的主要成分之一，可减轻糖尿病肾病（DN）中的氧化应激和炎症。然而，藏红花苷治疗 DN 的具体机制仍需进一步阐明。

方法

本研究首先建立了糖尿病肾病小鼠模型，以研究藏红花苷对糖尿病肾病小鼠的治疗作用。随后，采用非靶向代谢组学技术分析藏红花苷治疗 DN 的作用机制。还研究了藏红花苷对 CYP4A11/PPARγ 和 TGF-β/Smad 通路的影响。

结果

结果表明，藏红花苷对糖尿病肾病小鼠具有显著的治疗作用、抗炎作用和抗氧化作用。此外，非靶向代谢组学结果表明，藏红花苷治疗影响了肾脏中的几种代谢物。这些代谢物主要与生物素代谢、核黄素代谢和花生四烯酸代谢有关。此外，藏红花苷治疗可上调糖尿病肾病小鼠肾脏中 CYP4A11 和磷酸化 PPARγ 的降低水平，并降低 TGF-β1 和磷酸化 Smad2/3 的增加水平。

结论

综上所述，本研究验证了藏红花苷对糖尿病肾病小鼠具有显著的治疗、抗炎和抗氧化作用。藏红花苷治疗的机制可能与调节生物素、核黄素和花生四烯酸代谢、激活 CYP4A11/PPARγ 通路以及抑制肾脏中 TGF-β/Smad 通路有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c44/10825796/76ed984af9c3/CDM-24-709_F6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c44/10825796/5f59417c3cc4/CDM-24-709_F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c44/10825796/7703fd382b1d/CDM-24-709_F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c44/10825796/d4f14ee9171b/CDM-24-709_F3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c44/10825796/518f2064574f/CDM-24-709_F4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c44/10825796/2dfff3b7dfba/CDM-24-709_F5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c44/10825796/76ed984af9c3/CDM-24-709_F6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c44/10825796/5f59417c3cc4/CDM-24-709_F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c44/10825796/7703fd382b1d/CDM-24-709_F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c44/10825796/d4f14ee9171b/CDM-24-709_F3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c44/10825796/518f2064574f/CDM-24-709_F4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c44/10825796/2dfff3b7dfba/CDM-24-709_F5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c44/10825796/76ed984af9c3/CDM-24-709_F6.jpg

相似文献

1
Crocin Ameliorates Diabetic Nephropathy through Regulating Metabolism, CYP4A11/PPARγ, and TGF-β/Smad Pathways in Mice.藏红花酸通过调节代谢、CYP4A11/PPARγ 和 TGF-β/Smad 通路改善糖尿病肾病小鼠模型。
Curr Drug Metab. 2023;24(10):709-722. doi: 10.2174/0113892002257928231031113337.
2
A bioinformatics and network pharmacology approach to the mechanisms of action of Shenxiao decoction for the treatment of diabetic nephropathy.基于生物信息学和网络药理学的方法探讨参消汤治疗糖尿病肾病的作用机制。
Phytomedicine. 2020 Apr;69:153192. doi: 10.1016/j.phymed.2020.153192. Epub 2020 Feb 22.
3
Fuxin Granules ameliorate diabetic nephropathy in db/db mice through TGF-β1/Smad and VEGF/VEGFR2 signaling pathways.阜欣颗粒通过 TGF-β1/Smad 和 VEGF/VEGFR2 信号通路改善 db/db 小鼠的糖尿病肾病。
Biomed Pharmacother. 2021 Sep;141:111806. doi: 10.1016/j.biopha.2021.111806. Epub 2021 Jul 7.
4
Cyanidin-3-glucoside from Black Rice Ameliorates Diabetic Nephropathy via Reducing Blood Glucose, Suppressing Oxidative Stress and Inflammation, and Regulating Transforming Growth Factor β1/Smad Expression.黑米花色苷通过降低血糖、抑制氧化应激和炎症反应以及调节转化生长因子β1/Smad 表达来改善糖尿病肾病。
J Agric Food Chem. 2020 Apr 15;68(15):4399-4410. doi: 10.1021/acs.jafc.0c00680. Epub 2020 Mar 25.
5
[Effects of centella asiatica granule on the expression of TGF-β and related down-stream signals in rats with early diabetic nephropathy].积雪草颗粒对早期糖尿病肾病大鼠TGF-β及相关下游信号表达的影响
Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2018 Jan 8;34(1):69-73. doi: 10.12047/j.cjap.5528.2018.018.
6
Acetylshikonin from Zicao ameliorates renal dysfunction and fibrosis in diabetic mice by inhibiting TGF-β1/Smad pathway.紫草素通过抑制 TGF-β1/Smad 通路改善糖尿病小鼠的肾功能障碍和纤维化。
Hum Cell. 2018 Jul;31(3):199-209. doi: 10.1007/s13577-017-0192-8. Epub 2018 Mar 17.
7
[The Role of TGF-β1/SMAD in Diabetic Nephropathy: Mechanisms and Research Development].[转化生长因子-β1/信号转导和转录激活因子在糖尿病肾病中的作用：机制与研究进展]
Sichuan Da Xue Xue Bao Yi Xue Ban. 2023 Nov 20;54(6):1065-1073. doi: 10.12182/20231160108.
8
β-N-Oxalyl-L-α,β-diaminopropionic acid from Panax notoginseng plays a major role in the treatment of type 2 diabetic nephropathy.三七中的β-N-草酰基-L-α,β-二氨基丙酸在治疗 2 型糖尿病肾病方面起着重要作用。
Biomed Pharmacother. 2019 Jun;114:108801. doi: 10.1016/j.biopha.2019.108801. Epub 2019 Mar 28.
9
Combination of mulberry leaf active components possessed synergetic effect on SD rats with diabetic nephropathy by mediating metabolism, Wnt/β-catenin and TGF-β/Smads signaling pathway.桑叶活性成分的组合通过调节代谢、Wnt/β-catenin 和 TGF-β/Smads 信号通路对糖尿病肾病 SD 大鼠具有协同作用。
J Ethnopharmacol. 2022 Jun 28;292:115026. doi: 10.1016/j.jep.2022.115026. Epub 2022 Jan 22.
10
Imperatorin ameliorates kidney injury in diabetic mice by regulating the TGF-β/Smad2/3 signaling axis, epithelial-to-mesenchymal transition, and renal inflammation.欧前胡素通过调节TGF-β/Smad2/3信号轴、上皮-间质转化和肾脏炎症来改善糖尿病小鼠的肾损伤。
Eur J Pharmacol. 2024 Jan 15;963:176250. doi: 10.1016/j.ejphar.2023.176250. Epub 2023 Dec 12.

引用本文的文献

1
The circadian rhythm: A new target of natural products that can protect against diseases of the metabolic system, cardiovascular system, and nervous system.昼夜节律：天然产物的一个新靶点，可预防代谢系统、心血管系统和神经系统疾病。
J Adv Res. 2025 Mar;69:495-514. doi: 10.1016/j.jare.2024.04.005. Epub 2024 Apr 15.

本文引用的文献

1
The Effect of Saffron (Crocus sativus L.) Supplementation on Renal Function: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials.藏红花（Crocus sativus L.）补充剂对肾功能的影响：随机对照临床试验的系统评价和荟萃分析。
Int J Clin Pract. 2022 Aug 29;2022:9622546. doi: 10.1155/2022/9622546. eCollection 2022.
2
Gasdermin D is involved in switching from apoptosis to pyroptosis in TLR4-mediated renal tubular epithelial cells injury in diabetic kidney disease.Gasdermin D 参与了 TLR4 介导的糖尿病肾病肾小管上皮细胞损伤中细胞凋亡向细胞焦亡的转换。
Arch Biochem Biophys. 2022 Sep 30;727:109347. doi: 10.1016/j.abb.2022.109347. Epub 2022 Jul 7.
3
Ombuin ameliorates diabetic nephropathy in rats by anti-inflammation and antifibrosis involving Notch 1 and PPAR γ signaling pathways.
奥姆宾通过抑制 Notch1 和 PPARγ 信号通路减轻糖尿病肾病大鼠的炎症和纤维化。
Drug Dev Res. 2022 Sep;83(6):1270-1280. doi: 10.1002/ddr.21956. Epub 2022 Jun 7.
4
Crocin protects the renal tubular epithelial cells against high glucose-induced injury and oxidative stress via regulation of the SIRT1/Nrf2 pathway.藏红花素通过调节SIRT1/Nrf2信号通路保护肾小管上皮细胞免受高糖诱导的损伤和氧化应激。
Iran J Basic Med Sci. 2022 Feb;25(2):193-197. doi: 10.22038/IJBMS.2022.51597.11708.
5
Green tea peptides ameliorate diabetic nephropathy by inhibiting the TGF-β/Smad signaling pathway in mice.绿茶肽通过抑制小鼠体内的TGF-β/Smad信号通路改善糖尿病肾病。
Food Funct. 2022 Mar 21;13(6):3258-3270. doi: 10.1039/d1fo03615g.
6
Association of Urinary Sodium Excretion and Diabetic Kidney Disease in Patients With Type 2 Diabetes Mellitus: A Cross-Sectional Study.2 型糖尿病患者尿钠排泄与糖尿病肾病的相关性：一项横断面研究。
Front Endocrinol (Lausanne). 2021 Oct 28;12:772073. doi: 10.3389/fendo.2021.772073. eCollection 2021.
7
Phytochemistry, pharmacology, and potential clinical applications of saffron: A review.藏红花的植物化学、药理学和潜在临床应用：综述。
J Ethnopharmacol. 2021 Dec 5;281:114555. doi: 10.1016/j.jep.2021.114555. Epub 2021 Aug 23.
8
Recent advances in diabetic kidney disease.糖尿病肾病的最新进展
BMC Med. 2021 Aug 17;19(1):180. doi: 10.1186/s12916-021-02050-0.
9
Fuxin Granules ameliorate diabetic nephropathy in db/db mice through TGF-β1/Smad and VEGF/VEGFR2 signaling pathways.阜欣颗粒通过 TGF-β1/Smad 和 VEGF/VEGFR2 信号通路改善 db/db 小鼠的糖尿病肾病。
Biomed Pharmacother. 2021 Sep;141:111806. doi: 10.1016/j.biopha.2021.111806. Epub 2021 Jul 7.
10
Crocin alleviates the inflammation and oxidative stress responses associated with diabetic nephropathy in rats via NLRP3 inflammasomes.藏红花酸通过 NLRP3 炎性小体减轻大鼠糖尿病肾病的炎症和氧化应激反应。
Life Sci. 2021 Aug 1;278:119542. doi: 10.1016/j.lfs.2021.119542. Epub 2021 Apr 26.