Hospital de Clínicas de Porto Alegre, Laboratório de Doenças Autoimunes, Porto Alegre, Brazil.
Universidade Federal do Rio Grande do Sul, Faculdade de Medicina, Porto Alegre, Brazil.
PLoS One. 2023 Nov 8;18(11):e0286342. doi: 10.1371/journal.pone.0286342. eCollection 2023.
The aim of this study was to evaluate the function of a cohort of patients with rheumatoid arthritis (RA) from the core set of the International Classification of Functioning and Health (ICF) for RA over 12 months.
We used prospective longitudinal data to conduct a cohort study among a well-characterized group of RA patients. Ninety RA patients aged between 40 and 70 years were included in the study. Patients were evaluated at baseline and after 12 months. Age, disease duration, current smoking, erosions, disease activity, functional test, disability and physical activity were evaluated. Then, the ICF core set classification for RA was applied.
81 patients completed the assessments, the majority of patients were female (88.9%) and the mean age was 56.5 ± 7.3 years. At baseline, the median disease activity was 3.0. There was a statistically significant (p < 0.02) improvement in "Exercise tolerance functions" over 12 months and also a statistically significant (p < 0.001) decrease in "Muscle strength functions" over 12 months. The activity and participation domain showed a weak correlation with the clinical data of the DAS28-PCR (p<0.02).
We conclude that relevant aspects of the ICF Core Set for RA were able to adequately express the physical and functional factors of the RA cohort. This tool provides a common language for the interdisciplinary team, which can enhance the use of timely interventions to prevent physical disability in clinical practice.
本研究旨在评估一组类风湿关节炎(RA)患者的功能,这些患者来自国际功能、残疾和健康分类(ICF)RA 的核心组,随访时间为 12 个月。
我们使用前瞻性纵向数据,对一组特征明确的 RA 患者进行队列研究。共纳入 90 名年龄在 40-70 岁之间的 RA 患者。患者在基线和 12 个月时进行评估。评估内容包括年龄、疾病持续时间、当前吸烟状况、侵蚀、疾病活动度、功能测试、残疾和体力活动。然后,应用 ICF 核心组 RA 分类。
81 名患者完成了评估,大多数患者为女性(88.9%),平均年龄为 56.5±7.3 岁。基线时,疾病活动度中位数为 3.0。在 12 个月时,“运动耐量功能”有统计学意义的(p<0.02)改善,“肌肉力量功能”在 12 个月时也有统计学意义的(p<0.001)下降。活动和参与领域与 DAS28-PCR 的临床数据显示出弱相关性(p<0.02)。
我们得出结论,RA 的 ICF 核心组的相关方面能够充分表达 RA 队列的身体和功能因素。该工具为跨学科团队提供了一种通用语言,可增强在临床实践中及时干预以预防身体残疾的能力。