Department of Cardiology in Internal Medicine, School of Medicine, Chungnam National University, Chungnam National University Hospital, Daejeon, Korea.
Department of Preventive Medicine, Chungnam National University Hospital, Daejeon, Korea.
Am J Hypertens. 2024 Feb 15;37(3):168-178. doi: 10.1093/ajh/hpad106.
Left ventricular diastolic dysfunction (LVDD) is often associated with elevated blood pressure (BP). It is prevalent among hypertensive patients. Additionally, increased BP variability has been linked to LVDD. However, the precise connection between LVDD and BP variability within the general population remains unclear. Thus, this study aimed to evaluate this association in a general population.
A total of 2,578 participants(1,311 females) with a mean age of 47.8 ± 6.7 years who had echocardiographic data from the Korean Genome and Epidemiology study with 16 years of follow-up were analyzed. LVDD was identified through the last echocardiography during the follow-up period. BP variability was assessed using mean, standard deviation (SD), and coefficient of variance (CV).
LVDD was detected in 249 individuals. The cohort was divided into an LVDD group and a normal LV diastolic function group. The LVDD group had a higher percentage of females, more advanced age, higher body mass index (BMI), higher BP and BUN levels, lower heart rate, lower hemoglobin, and lower serum creatinine than the normal LV diastolic function group. Remarkably, LVDD was associated with higher BP variability. In the multivariate analysis, LVDD was associated with increased age, female sex, increased BMI, hypertension, and increased BUN. Elevated mean systolic and diastolic BPs, SD of systolic BP, mean pulse pressure (PP), SD of PP, and CV of PP were significantly linked to LVDD even after adjusting for other significant variables in the multivariate analysis.
LVDD was identified in 249 (9.7%) participants. Increased long-term BP variability was significantly associated with LVDD in this population-based cohort.
左心室舒张功能障碍（LVDD）常与血压升高（BP）相关。它在高血压患者中较为普遍。此外，BP 变异性增加与 LVDD 相关。然而，一般人群中 LVDD 与 BP 变异性之间的确切联系尚不清楚。因此，本研究旨在评估一般人群中的这种相关性。
共分析了来自韩国基因组与流行病学研究（Korean Genome and Epidemiology study）的 2578 名参与者（1311 名女性，平均年龄 47.8±6.7 岁）的超声心动图数据，随访时间为 16 年。LVDD 通过随访期间的最后一次超声心动图来确定。BP 变异性使用均值、标准差（SD）和变异系数（CV）来评估。
在 249 名个体中检测到 LVDD。该队列分为 LVDD 组和正常 LV 舒张功能组。LVDD 组女性比例较高，年龄较大，体重指数（BMI）较高，BP 和 BUN 水平较高，心率较低，血红蛋白较低，血清肌酐较低。值得注意的是，LVDD 与更高的 BP 变异性相关。多变量分析显示，LVDD 与年龄增加、女性、BMI 增加、高血压和 BUN 增加相关。即使在校正多变量分析中的其他显著变量后，平均收缩压和舒张压升高、收缩压 SD、平均脉搏压（PP）、PP 的 SD 和 PP 的 CV 与 LVDD 显著相关。
在 249 名（9.7%）参与者中确定了 LVDD。在这个基于人群的队列中，长期 BP 变异性增加与 LVDD 显著相关。
