Xu Xuefeng, Han Yi, Zhu Tianxin, Fan Faxin, Wang Xin, Liu Yuqing, Luo Duosheng
Key Laboratory of Glucolipid Metabolic Disorder, Ministry of Education of China, China; Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine, China; Guangdong TCM Key Laboratory for Metabolic Diseases, Guangzhou 510006, China; Institute of Chinese Medicine, Guangdong Pharmaceutical University, China.
Key Laboratory of Glucolipid Metabolic Disorder, Ministry of Education of China, China; Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine, China; Guangdong TCM Key Laboratory for Metabolic Diseases, Guangzhou 510006, China; Institute of Chinese Medicine, Guangdong Pharmaceutical University, China.
Biomed Pharmacother. 2023 Dec 31;169:115838. doi: 10.1016/j.biopha.2023.115838. Epub 2023 Nov 7.
There are a large number of people worldwide who suffer from osteoporosis, which imposes a huge economic burden, so it is necessary to explore the underlying mechanisms to achieve better supportive and curative care outcomes. Sphingosine kinase (SphK) is an enzyme that plays a crucial role in the synthesis of sphingosine-1-phosphate (S1P). S1P with paracrine and autocrine activities that act through its cell surface S1P receptors (S1PRs) and intracellular signals. In osteoporosis, S1P is indispensable for both normal and disease conditions. S1P has complicated roles in regulating osteoblast and osteoclast, respectively, and there have been exciting developments in understanding how SphK/S1P/S1PR signaling regulates these processes in response to osteoporosis therapy. Here, we review the proliferation, differentiation, apoptosis, and functions of S1P, specifically detailing the roles of S1P and S1PRs in osteoblasts and osteoclasts. Finally, we focus on the S1P-based therapeutic approaches in bone metabolism, which may provide valuable insights into potential therapeutic strategies for osteoporosis.
全球有大量的人患有骨质疏松症，这带来了巨大的经济负担，因此有必要探索其潜在机制，以实现更好的支持性和治愈性护理效果。鞘氨醇激酶（SphK）是一种在鞘氨醇-1-磷酸（S1P）合成中起关键作用的酶。S1P具有旁分泌和自分泌活性，通过其细胞表面S1P受体（S1PRs）和细胞内信号发挥作用。在骨质疏松症中，S1P在正常和疾病状态下都是不可或缺的。S1P在调节成骨细胞和破骨细胞方面具有复杂的作用，在理解SphK/S1P/S1PR信号如何响应骨质疏松症治疗来调节这些过程方面已经有了令人兴奋的进展。在这里，我们综述了S1P的增殖、分化、凋亡及功能，特别详细阐述了S1P和S1PRs在成骨细胞和破骨细胞中的作用。最后，我们聚焦于基于S1P的骨代谢治疗方法，这可能为骨质疏松症的潜在治疗策略提供有价值的见解。
