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皮下注射维多珠单抗的应用:奥地利胃肠病学和肝病学会(ÖGGH)炎症性肠病工作组发布的立场文件

[Use of subcutaneous Vedolizumab: A position paper issued by the Inflammatory Bowel Disease Working Group of the Austrian Society of Gastroenterology and Hepatology (ÖGGH)].

作者信息

Reider Simon, Novacek Gottfried, Haas Thomas, Gröchenig Hans-Peter, Platzer Reingard, Koch Robert, Kump Patrizia Katharina, Reinisch Walter, Moschen Alexander

机构信息

Universitätsklinik für Innere Medizin mit Schwerpunkt Gastroenterologie und Hepatologie, Kepler Universitätsklinikum Gmbh, Johannes Kepler Universität Linz, Linz, Austria.

Christian Doppler Labor für Mukosale Immunologie, Johannes Kepler Universität Linz, Linz, Austria.

出版信息

Z Gastroenterol. 2023 Nov;61(11):1518-1525. doi: 10.1055/a-2150-2156. Epub 2023 Sep 20.

Abstract

The humanized monoclonal anti-α4β7-integrin-antibody vedolizumab is one of several biologic therapeutic options in moderate-to-severe ulcerative colitis and Crohn's disease. Within the VISIBLE trial program, a novel subcutaneous application route was evaluated in addition to the already established intravenous form. In this position statement, the working group "Inflammatory Bowel Diseases" of the Austrian Society for Gastroenterology and Hepatology (OEGGH) summarizes the evidence regarding the subcutaneous application of vedolizumab. This work supplements a position paper on the value of vedolizumab as a first-line biologic that has already been published and offers useful recommendations for clinical practice.

摘要

人源化抗α4β7整合素单克隆抗体维多珠单抗是中重度溃疡性结肠炎和克罗恩病的几种生物治疗选择之一。在VISIBLE试验项目中,除了已确定的静脉给药形式外,还评估了一种新型皮下给药途径。在本立场声明中,奥地利胃肠病学和肝病学会(OEGGH)的“炎症性肠病”工作组总结了关于维多珠单抗皮下给药的证据。这项工作补充了一篇已发表的关于维多珠单抗作为一线生物制剂价值的立场文件,并为临床实践提供了有用的建议。

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