Division of Dermatology, Department of Medicine, University of Toronto School of Medicine, Toronto, Ontario, Canada.
Mediprobe Research Inc., London, Ontario, Canada;
Skinmed. 2023 Nov 10;21(5):360-363. eCollection 2023.
YCANTH (cantharidin) topical solution has been approved recently for the treatment of molluscum contagiosum (MC) in children (aged ≥2 years) and adults. It works by activating serine proteases that lead to blistering and inflammation, promoting shedding of infected cells and viral clearance. In two phase-3, randomized, double-blind, vehicle-controlled trials of similar design, VP-102 (a drug-device combination, containing cantharidin 0.7% w/v and inactive ingredients, such as gentian violet, acetone, and denatonium benzoate, administered with an applicator) was investigated for the treatment of MC. VP-102 and vehicle were applied topically once every 21 days until complete clearance of lesions was observed, or for up to four treatments. Cantharidin demonstrated efficacy in achieving the primary outcome, at day 84/visit 4 (Cantharidin Application in Molluscum Patients [CAMP-1], VP-102: 46% [73/160], vehicle: 18% [19/106]; and CAMP-2, VP-102: 54% [81/150], vehicle: 13% [15/112]). Common adverse events were mild to moderate, such as lesions at the site of application, pruritus, and pain. The recommended regimen of cantharidin topical solution is its application once every 21 days until complete clearance of lesions is observed, or up to four treatments.
YCANTH（斑蝥素）局部溶液最近已被批准用于治疗儿童（≥2 岁）和成人的传染性软疣。它通过激活丝氨酸蛋白酶，导致水疱和炎症，促进受感染细胞的脱落和病毒清除。在两项类似设计的 3 期、随机、双盲、安慰剂对照试验中，VP-102（一种药物-器械组合，含有 0.7%w/v 的斑蝥素和非活性成分，如龙胆紫、丙酮和苯甲地那铵，用涂抹器给药）被用于治疗 MC。VP-102 和安慰剂每 21 天局部涂抹一次，直到观察到皮损完全清除，或最多进行 4 次治疗。斑蝥素在第 84 天/第 4 次就诊时（传染性软疣患者的斑蝥素应用[CAMP-1]，VP-102：46%[73/160]，安慰剂：18%[19/106]；和 CAMP-2，VP-102：54%[81/150]，安慰剂：13%[15/112]）达到了主要终点，显示出疗效。常见的不良反应为轻度至中度，如用药部位皮损、瘙痒和疼痛。斑蝥素局部溶液的推荐治疗方案是每 21 天局部涂抹一次，直到观察到皮损完全清除，或最多进行 4 次治疗。
