genotyping and the clinical impact on outcomes in breast cancer tamoxifen-treated patients.

To report the distribution of allele frequencies of gene and to evaluate their influence on the clinical outcomes of a group of breast cancer patients receiving adjuvant tamoxifen treatment from Uruguay. 199 samples were genotyped through real-time polymerase chain reaction assays. Metabolization profiles were inferred from the genotypes. Correlations were evaluated using Pearson's χ test. Phenotype frequencies were 0.65 normal (NM), 0.30 intermediate (IM) and 0.05 poor metabolizers (PM). Similar clinical outcomes between NM and (PM + IM) patient groups (odds ratio = 1.011, 95% CI = 0.2703-3.7826; p = 0.987) were found. CYP2D6 allele frequencies were analyzed for the first time in a cohort from Uruguay. Results did not support any impact of gene polymorphisms on clinical outcomes.