Kusano Yuki, Den Seika, Yamaguchi Takefumi, Nishisako Sota, Fukui Masaki, Shimazaki Jun
Department of Ophthalmology, Tokyo Dental College Ichikawa General Hospital, Chiba, Japan.
Department of Ophthalmology, Kumamoto Shinto General Hospital, Kumamoto, Japan.
Cornea. 2024 Jun 1;43(6):740-745. doi: 10.1097/ICO.0000000000003422. Epub 2023 Nov 9.
The aim of this study was to identify the postoperative recurrence rate of recurrent pterygium and to evaluate risk factors for the recurrence.
This study was a retrospective interventional nonrandomized consecutive case series. In this single-center study, 119 eyes of patients with recurrent pterygium who underwent surgery with a follow-up period of >12 months after the surgery were analyzed. The clinical characteristics of pterygium were classified according to the length of corneal involvement and Tan grade. The main outcome was the recurrence rate. The secondary outcome was the risk factors for recurrence.
The mean follow-up period was 42 ± 28.6 months. Recurrence was observed in 15 patients (12.6%). The average postoperative recurrence period was 7.7 ± 6.7 months. Twelve patients experienced a recurrence within 12 months. Eyes with recurrence had a significantly greater length of corneal involvement (2.47 ± 0.72 mm) and number of previous surgery (1.9 ± 1.3) than those without (1.97 ± 0.74 mm, and 1.3 ± 0.7, both P = 0.04). Multivariate analysis showed that recurrence was significantly associated with the length of corneal involvement (odds ratio [OR] 2.38, 95% confidence interval [CI], 1.02-5.57, P = 0.05) and the number of previous surgeries (OR: 1.91, 95% CI, 1.03-3.58, P = 0.04) but not with sex (OR: 3.71, 95% CI, 0.90-15.2, P = 0.07), age (OR: 0.99, 95% CI, 0.94-1.04, P = 0.59), and use of mitomycin C (OR: 0.31, 95% CI, 0.07-1.21, P = 0.09).
The postoperative recurrence rate of recurrent pterygium was 12.6%. The preoperative length of corneal involvement and number of previous pterygium surgeries were significantly correlated with recurrence. Male sex and nonuse of mitomycin C tended to correlate with recurrence.
本研究旨在确定复发性翼状胬肉的术后复发率，并评估复发的危险因素。
本研究为回顾性干预非随机连续病例系列。在这个单中心研究中，分析了119例接受手术的复发性翼状胬肉患者的眼睛，术后随访时间超过12个月。根据角膜受累长度和Tan分级对翼状胬肉的临床特征进行分类。主要结局是复发率。次要结局是复发的危险因素。
平均随访时间为42±28.6个月。15例患者（12.6%）出现复发。术后平均复发时间为7.7±6.7个月。12例患者在12个月内复发。复发患者的角膜受累长度（2.47±0.72mm）和既往手术次数（1.9±1.3）明显高于未复发患者（分别为1.97±0.74mm和1.3±0.7，P均=0.04）。多因素分析显示，复发与角膜受累长度（比值比[OR]2.38，95%置信区间[CI]，1.02 - 5.57，P = 0.05）和既往手术次数（OR：1.91，95%CI，1.03 - 3.58，P = 0.04）显著相关，但与性别（OR：3.71，95%CI，0.90 - 15.2，P = 0.07）、年龄（OR：0.99，95%CI，0.94 - 1.04，P = 0.59）和丝裂霉素C的使用（OR：0.31，95%CI，0.07 - 1.21，P = 0.09）无关。
复发性翼状胬肉的术后复发率为12.6%。术前角膜受累长度和既往翼状胬肉手术次数与复发显著相关。男性和未使用丝裂霉素C与复发有一定相关性。
