Khorasani Milad
Healthy Ageing Research Centre, Neyshabur University of Medical Sciences, Neyshabur, Iran; Department of Biochemistry and Nutrition, Neyshabur University of Medical Sciences, Neyshabur, Iran.
Cytokine. 2024 Jan;173:156422. doi: 10.1016/j.cyto.2023.156422. Epub 2023 Nov 8.
Colorectal cancer (CRC) is a common and deadly form of cancer, leading to the need for new therapeutic targets and strategies for treatment. Recent studies have shown the cGAS-STING pathway to be a promising target for cancer therapy. The cGAS-STING pathway is a part of the innate immune system and serves to identify DNA damage and viral infection, promoting an immune response. Activation of this pathway leads to the production of immune mediators, such as type I interferons, that activate immune cells to attack cancer cells. Research has identified the cGAS-STING pathway as a frequently dysregulated component in CRC, promoting tumor growth and metastasis, or leading to chronic inflammation and tissue damage. The modulation of this pathway presents a potential therapeutic approach, either activating or inhibiting the pathway to enhance the immune response and prevent inflammation, respectively. Developing drugs that can modulate the cGAS-STING pathway offers promise for improving treatment outcomes for CRC patients. The present review explores recent research on the role of cGAS-STING in CRC and highlights the potential therapeutic benefits of targeting this pathway.
结直肠癌（CRC）是一种常见且致命的癌症形式，这导致需要新的治疗靶点和治疗策略。最近的研究表明，cGAS-STING通路是癌症治疗的一个有前景的靶点。cGAS-STING通路是先天免疫系统的一部分，用于识别DNA损伤和病毒感染，促进免疫反应。该通路的激活会导致免疫介质的产生，如I型干扰素，其可激活免疫细胞来攻击癌细胞。研究已确定cGAS-STING通路是CRC中经常失调的成分，促进肿瘤生长和转移，或导致慢性炎症和组织损伤。对该通路的调节提出了一种潜在的治疗方法，即分别激活或抑制该通路以增强免疫反应和预防炎症。开发能够调节cGAS-STING通路的药物有望改善CRC患者的治疗效果。本综述探讨了关于cGAS-STING在CRC中作用的最新研究，并强调了靶向该通路的潜在治疗益处。
